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Title: | Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response |
Author: | Pinazo, Maria-Jesus Posada, Elizabeth Izquierdo Lázaro, Luis Tàssies Penella, María Dolores Ferreira Marques, Alexandre Lazzari, Elisa de Aldasoro, Edelweiss Muñoz, José Abras Feliu, Alba Tebar, Silvia Gállego Culleré, M. (Montserrat) Almeida, Igor Correia de Reverter Calatayud, Juan Carlos Gascón i Brustenga, Joaquim |
Keywords: | Hemostàsia Malalties parasitàries Malaltia de Chagas Hemostasis Parasitic diseases Chagas' disease |
Issue Date: | 2016 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0004269 |
It is part of: | PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 1, p. e0004269 |
URI: | http://hdl.handle.net/2445/112005 |
Related resource: | https://doi.org/10.1371/journal.pntd.0004269 |
ISSN: | 1935-2735 |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) Articles publicats en revistes (ISGlobal) |
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