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DC Field | Value | Language |
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dc.contributor.author | Graupera, Isabel | - |
dc.contributor.author | Solà, Elsa | - |
dc.contributor.author | Fabrellas i Padrès, Núria | - |
dc.contributor.author | Moreira, Rebeca | - |
dc.contributor.author | Solé Padullés, Cristina | - |
dc.contributor.author | Huelin, Patricia | - |
dc.contributor.author | de la Prada, Gloria | - |
dc.contributor.author | Pose, Elisa | - |
dc.contributor.author | Ariza Cardenal, Javier | - |
dc.contributor.author | Risso, Alessandro | - |
dc.contributor.author | Albertos, Sonia | - |
dc.contributor.author | Morales Ruiz, Manuel | - |
dc.contributor.author | Jiménez Povedano, Wladimiro | - |
dc.contributor.author | Ginès i Gibert, Pere | - |
dc.date.accessioned | 2017-06-06T11:35:30Z | - |
dc.date.available | 2017-06-06T11:35:30Z | - |
dc.date.issued | 2016-06-30 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112008 | - |
dc.description.abstract | MCP-1 (monocyte chemoattractant protein-1) is a proinflammatory cytokine involved in chemotaxis of monocytes. In several diseases, such as acute coronary syndromes and heart failure, elevated MCP-1 levels have been associated with poor outcomes. Little is known about MCP-1 in cirrhosis. AIM: To investigate the relationship between MCP-1 and outcome in decompensated cirrhosis. METHODS: Prospective study of 218 patients discharged from hospital after an admission for complications of cirrhosis. Urine and plasma levels of MCP-1 and other urine proinflammatroy biomarkers: osteopontin(OPN), trefoil-factor3 and liver-fatty-acid-binding protein were measured at admission. Urine non-inflammatory mediators cystatin-C, β2microglobulin and albumin were measured as control biomarkers. The relationship between these biomarkers and the 3-month hospital readmission, complications of cirrhosis, and mortality were assessed. RESULTS: 69 patients(32%) had at least one readmission during the 3-month period of follow-up and 30 patients died(14%). Urine MCP-1 and OPN levels, were associated with 3-month probability of readmission (0.85 (0.27-2.1) and 2003 (705-4586) ug/g creat vs 0.47 (0.2-1.1) and 1188 (512-2958) ug/g creat, in patients with and without readmission, respectively; p<0.05; median (IQR)). Furthermore, urine levels of MCP-1 were significantly associated with mortality (1.01 (1-3.6) vs 0.5 (0.2-1.1) μg/g creat, in dead and alive patients at 3 months; p<0.05). Patients with higher levels of urine MCP-1 (above percentile 75th) had higher probability of development of hepatic encephalopathy, bacterial infections or AKI. Urine MCP-1 was an independent predictive factor of hospital readmission and combined end-point of readmission or dead at 3 months. Plasma levels of MCP-1 did not correlated with outcomes. CONCLUSION: Urine, but not plasma, MCP-1 levels are associated with hospital readmission, development of complications of cirrhosis, and mortality. These results suggest that in cirrhosis there is an inflammatory response that is associated with poor outcomes. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0157371 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 6 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0157371 | - |
dc.rights | cc-by (c) Graupera, Isabel et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Cirrosi hepàtica | - |
dc.subject.classification | Orina | - |
dc.subject.classification | Creatina | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Ascites | - |
dc.subject.other | Hepatic cirrhosis | - |
dc.subject.other | Urine | - |
dc.subject.other | Creatine | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Ascites | - |
dc.title | Urine Monocyte Chemoattractant Protein-1 Is an Independent Predictive Factor of Hospital Readmission and Survival in Cirrhosis. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 666256 | - |
dc.date.updated | 2017-06-06T11:35:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27359339 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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