Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/112251
Title: | Genome editing in human pluripotent stem cells: a systematic approach unrevealing pancreas development and disease |
Author: | Garreta, Elena Marco, Andrés Izpisúa Belmonte, Juan Carlos Montserrat, Núria |
Keywords: | Malalties hereditàries Genètica humana Malalties del pàncrees Genetic diseases Genètica humana Pancréas diseases |
Issue Date: | 14-Nov-2016 |
Publisher: | AME |
Abstract: | Although mouse models have represented a major tool for understanding and predicting molecular mechanisms responsible for several human genetic diseases, still species-specific differences between mouse and humans in their biochemical and physiological characteristics represent a major hurdle when translating promising findings into the human setting (1). For instance, in several types of maturity onset diabetes of the young (MODY; autosomal dominant), mice with heterozygous mutations do not develop diabetes (2). In this regard, the derivation of human embryonic stem cells (hESCs) in 1998 represented an unprecedented opportunity for human disease modelling, and a promising source for cell replacement therapies (3). Later on, the possibility to generate patient-derived induced pluripotent stem cells (iPSCs) has opened new venues for the potential translation of stem-cell related studies into the clinic (4). |
Note: | Reproducció del document publicat a: https://doi.org/10.21037/sci.2016.10.11 |
It is part of: | Stem Cell Investigation 2016, vol. 4, num. 11, p. 1-4 |
URI: | http://hdl.handle.net/2445/112251 |
Related resource: | http://dx.doi.org/10.21037/sci.2016.10.11 |
ISMN: | 2313-0792 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
L16_2016_Stem Cell Investigation_4_1.pdf | 148.23 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.