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Title: | Regenerative strategies for kidney engineering |
Author: | Montserrat, Núria Garreta, Elena Izpisúa Belmonte, Juan Carlos |
Keywords: | Cèl·lules mare Bioenginyeria Ronyó Stem cells Bioengineering Kidney |
Issue Date: | 1-Sep-2016 |
Publisher: | Wiley |
Abstract: | The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an immune regulator and modulator of cardiovascular physiology. The development of in vitro renal disease models with pluripotent stem cells (both human embryonic stem cells and induced pluripotent stem cells) and the generation of robust protocols for in vitro derivation of renal-specific-like cells from patient induced pluripotent stem cells have just emerged. Here we review major findings in the field of kidney regeneration with a major focus on the development of stepwise protocols for kidney cell production from human pluripotent stem cells and the latest advances in kidney bioengineering (i.e. decellularized kidney scaffolds and bioprinting). The possibility of generating renal-like three-dimensional structures to be recellularized with renal-derived induced pluripotent stem cells may offer new avenues to develop functional kidney grafts on-demand. |
Note: | Reproducció del document publicat a: https://doi.org/10.1111/febs.13704 |
It is part of: | FEBS Journal, 2016, vol. 283, num. 18, p. 3303-3324 |
URI: | http://hdl.handle.net/2445/112252 |
Related resource: | https://doi.org/10.1111/febs.13704 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) Publicacions de projectes de recerca finançats per la UE |
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L20_2016_FEBS Journal_283_3303.pdf | 287.84 kB | Adobe PDF | View/Open |
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