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http://hdl.handle.net/2445/112375Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mir Morro, Bartomeu | - |
| dc.contributor.author | Solés, X. | - |
| dc.contributor.author | González, Carlos | - |
| dc.contributor.author | Escaja Sánchez, Nuria | - |
| dc.date.accessioned | 2017-06-14T13:53:09Z | - |
| dc.date.available | 2017-06-14T13:53:09Z | - |
| dc.date.issued | 2017-06-05 | - |
| dc.identifier.issn | 2045-2322 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/112375 | - |
| dc.description.abstract | Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure. | - |
| dc.format.extent | 8 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Nature Publishing Group | - |
| dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-02723-y | - |
| dc.relation.ispartof | Scientific Reports, 2017, vol. 7, num. 2772 | - |
| dc.relation.uri | https://doi.org/10.1038/s41598-017-02723-y | - |
| dc.rights | cc-by (c) Mir Morro, Bartomeu et al., 2017 | - |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
| dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
| dc.subject.classification | Àcids nucleics | - |
| dc.subject.classification | Citidina difosfat de colina | - |
| dc.subject.classification | Oligonucleòtids | - |
| dc.subject.other | Nucleic acids | - |
| dc.subject.other | Cytidine diphosphate choline | - |
| dc.subject.other | Oligonucleotides | - |
| dc.title | The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.identifier.idgrec | 672099 | - |
| dc.date.updated | 2017-06-14T13:53:10Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| dc.identifier.pmid | 28584239 | - |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 672099.pdf | 2.56 MB | Adobe PDF | View/Open |
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