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http://hdl.handle.net/2445/112426
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DC Field | Value | Language |
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dc.contributor.author | Jimenez-Marco, Teresa | - |
dc.contributor.author | Riera Lizandra, Ma. Cristina | - |
dc.contributor.author | Girona-Llobera, Enrique | - |
dc.contributor.author | Guillen, Carmen | - |
dc.contributor.author | Iniesta González, Laura | - |
dc.contributor.author | Alcover Amengual, Maria Magdalena | - |
dc.contributor.author | Berenguer, Diana | - |
dc.contributor.author | Pujol Brugués, Alba | - |
dc.contributor.author | Tomás Pérez, Míriam | - |
dc.contributor.author | Cancino Faure, María Beatriz | - |
dc.contributor.author | Serra, Teresa | - |
dc.contributor.author | Mascaró, Martín | - |
dc.contributor.author | Gascó, Joan | - |
dc.contributor.author | Fisa Saladrigas, Roser | - |
dc.date.accessioned | 2017-06-15T16:12:47Z | - |
dc.date.available | 2017-06-15T16:12:47Z | - |
dc.date.issued | 2017-03-15 | - |
dc.identifier.issn | 1723-2007 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112426 | - |
dc.description.abstract | Background. In the Balearic Islands, as in other areas of the Mediterranean basin, there is a significant proportion of asymptomatic Leishmania (L.) infantum-infected blood donors, who may represent an important threat to transfusion safety. The Balearic Islands blood bank, located in an area endemic for L. infantum, carried out a study of donors and patients to investigate the impact of this infectious disease on blood safety in the region. Materials and methods. Twenty asymptomatic Leishmania-infected blood donors were followed-up between 2008 and 2011 to investigate the evolution of Leishmania infection in asymptomatic carriers. Their blood was periodically tested for anti-Leishmania antibodies by western blot and for Leishmania DNA by quantitative polymerase chain reaction (qPCR). Additionally, the prevalence of L. infantum infection was investigated in a group of 68 multiply transfused patients to ascertain the risk of transfusion-transmitted leishmaniasis (TTL) in the region, taking into account regular blood component production practices such as pre-storage leucodepletion and pathogen reduction technology. Results. All 20 donors remained asymptomatic over the study period (2008-2011). Most donors had repeatedly positive qPCR results, either persistently or intermittently, but showed no symptoms of Leishmaniasis. Levels of parasitaemia were remarkably low in asymptomatic donors, with values ≤1 parasite/mL. Despite multiple transfusions received over 15 years, no transfused patient studied was infected with L. infantum. Discussion. L. infantum-infected donors can remain asymptomatic for at least 3 years. In our region, no cases of TTL were detected, despite an active search in multiply transfused patients. This seems to be related to two independent variables: (i) a low concentration of the parasite in the peripheral blood of asymptomatic carriers and (ii) the application of methods with proven efficacy against TTL, such as leucodepletion and pathogen reduction technology. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Edizioni SIMTI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2450/2017.0201-16 | - |
dc.relation.ispartof | Blood Transfusion, 2017 | - |
dc.relation.uri | https://doi.org/10.2450/2017.0201-16 | - |
dc.rights | (c) Edizioni SIMTI, 2017 | - |
dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
dc.subject.classification | Leishmania infantum | - |
dc.subject.classification | Donants de sang | - |
dc.subject.classification | Transfusió de sang | - |
dc.subject.classification | Illes Balears | - |
dc.subject.other | Leishmania infantum | - |
dc.subject.other | Blood donors | - |
dc.subject.other | Blood transfusion | - |
dc.subject.other | Balearic Islands | - |
dc.title | Strategies for reducing the risk of transfusion-transmitted leishmaniasis in an area endemic for Leishmania infantum: a patient- and donor-targeted approach | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 671441 | - |
dc.date.updated | 2017-06-15T16:12:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28488962 | - |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
Files in This Item:
File | Description | Size | Format | |
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671441.pdf | 1.3 MB | Adobe PDF | View/Open |
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