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http://hdl.handle.net/2445/112443
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DC Field | Value | Language |
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dc.contributor.author | Jiménez, Amanda | - |
dc.contributor.author | Mari, Andrea | - |
dc.contributor.author | Casamitjana i Abellà, Roser | - |
dc.contributor.author | Lacy Fortuny, Antonio Ma. de | - |
dc.contributor.author | Ferrannini, Ele | - |
dc.contributor.author | Vidal i Cortada, Josep | - |
dc.date.accessioned | 2017-06-16T07:45:04Z | - |
dc.date.available | 2017-06-16T07:45:04Z | - |
dc.date.issued | 2014-05-21 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112443 | - |
dc.description.abstract | Although GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand the role of GLP-1 in the remission of type 2 diabetes mellitus (T2DM) long term after SG in humans, we conducted two separate cross-sectional studies: 1) the GLP-1 response to a standardized mixed liquid meal (SMLM) was compared in subjects with T2DM antedating SG but with different long-term (>2 years) T2DM outcomes (remission, relapse, or lack of remission) (study 1) and 2) the effect of GLP-1 receptor blockade with exendin (9-39) on glucose tolerance was examined in subjects with T2DM antedating surgery, who had undergone SG and presented with long-term T2DM remission (study 2). In study 1, we observed a comparable GLP-1 response to the SMLM regardless of the post-SG outcome of T2DM. In study 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of glucose tolerance. Thus, our data suggest the enhanced GLP-1 secretion observed long term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Diabetes Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.2337/db14-0357 | - |
dc.relation.ispartof | Diabetes, 2014, vol. 63, num. 10, p. 3372-3377 | - |
dc.relation.uri | https://doi.org/10.2337/db14-0357 | - |
dc.rights | cc-by-nc-nd (c) American Diabetes Association, 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Obesitat mòrbida | - |
dc.subject.classification | Diabetis no-insulinodependent | - |
dc.subject.classification | Cirurgia digestiva | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Morbid obesity | - |
dc.subject.other | Non-insulin-dependent diabetes | - |
dc.subject.other | Gastrointestinal surgery | - |
dc.subject.other | Case studies | - |
dc.title | GLP-1 and glucose tolerance after sleeve gastrectomy in morbidly obese subjects with type 2 diabetes. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 646688 | - |
dc.date.updated | 2017-06-16T07:45:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24848069 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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