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http://hdl.handle.net/2445/112543| Title: | Evidence of association of the NLRP1 gene with giant cell arteritis |
| Author: | Serrano, Aurora Carmona, F. David Castañeda, Santos Solans, Roser Hernández Rodríguez, José Cid Xutglà, M. Cinta Prieto González, Sergio Miranda-Filloy, José A. Rodríguez-Rodríguez, Luis Morado, Inmaculada C. Gómez Vaquero, Carmen Blanco, Ricardo Sopeña, Bernardo Ortego Centeno, Norberto Unzurrunzaga, Ainhoa Marí-Alfonso, Begoña Sánchez-Martin, Julio García-Villanueva, María Jesús Hidalgo-Conde, Ana Pazzola, Giulia Boiardi, Luigi Salvarani, Carlo González-Gay, Miguel A. Martín, Javier |
| Keywords: | Arteritis de cèl·lules gegants Polimorfisme genètic Genètica Giant cell arteritis Genetic polymorphisms Genetics |
| Issue Date: | Apr-2013 |
| Publisher: | BMJ Publishing Group |
| Abstract: | Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1136/annrheumdis-2012-202609 |
| It is part of: | Annals of the Rheumatic Diseases, 2013, vol. 72, num. 4, p. 628-630 |
| URI: | http://hdl.handle.net/2445/112543 |
| Related resource: | https://doi.org/10.1136/annrheumdis-2012-202609 |
| ISSN: | 0003-4967 |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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