Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/113202
Title: | Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants |
Author: | Bautista Rodríguez, Carles Launes Montaña, Cristian Jordán García, Iolanda Andrés, Maria Arias, Maria Teresa Lozano Soto, Francisco García García, Juan José Muñoz-Almagro, Carmen |
Keywords: | Meningitis Infeccions per pneumococs Infants Epidemiologia Salut pública Unitats de cures intensives Meningitis Pneumococcal Infections Children Epidemiology Public health Intensive care units |
Issue Date: | 31-May-2017 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | OBJECTIVES: The objective of this study was to evaluate to evaluate the role of mannose-binding-lectin deficient genotypes in pneumococcal meningitis (PM) in children. METHODS: We performed a 16-year retrospective study (January 2001 to March 2016) including patients ≤ 18 years with PM. Variables including attack rate of pneumococcal serotype (high or low invasive capacity) and MBL2 genotypes associated with low serum MBL levels were recorded. RESULTS: Forty-eight patients were included in the study. Median age was 18.5 months and 17/48 episodes (35.4%) occurred in children ≤ 12 months old. Serotypes with high-invasive disease potential were identified in 15/48 episodes (31.2%). MBL2 deficient genotypes accounted for 18.8% (9/48). Children ≤ 12 months old had a 7-fold risk (95% CI: 1.6-29.9; p < 0.01) of having a MBL2 deficient genotype in comparison to those > 12 months old. A sub-analysis of patients by age group revealed significant proportions of carriers of MBL2 deficient genotypes among those ≤ 12 months old with PM caused by opportunistic serotypes (54.5%), admitted to the PICU (Pediatric Intensive Care Unit) (46.7%) and of White ethnicity (35.7%). These proportions were significantly higher than in older children (all p<0.05). CONCLUSIONS: Our results suggest that differences in MBL2 genotype in children ≤12 months old affects susceptibility to PM, and it may have an important role in the episodes caused by non-high invasive disease potential serotypes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0178377 |
It is part of: | PLoS One, 2017, vol. 12, num. 5, p. e0178377 |
URI: | http://hdl.handle.net/2445/113202 |
Related resource: | https://doi.org/10.1371/journal.pone.0178377 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
672568.pdf | 825.83 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License