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Title: | Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer |
Author: | Royo, Felix Zúñiga García, Patricia Torrano, Verónica Loizaga Iriarte, Ana Sánchez Mosquera, Pilar Ugalde-Olano, Aitziber González, Esperanza Cortazar, Ana Rosa Palomo, Laura Fernández-Ruiz, Sonia Lacasa-Viscasillas, Isabel Berdasco, María Sutherland, James David Barrio, Rosa Zabala Letona, Amaia Martín-Martín, Natalia Arruabarrena-Aristorena, Amaia Valcarcel-Jimenez, Lorea Caro Maldonado, Alfredo Gonzalez-Tampan, Jorge Cachi-Fuentes, Guido Esteller, Manel Aransay, Ana M. Unda Urzaiz, Miguel Falcón Pérez, Juan Manuel Carracedo, Arkaitz |
Keywords: | Càncer de pròstata Malalties de la pròstata Marcadors tumorals Marcadors bioquímics Anàlisi d'orina Prostate cancer Prostatic diseases Tumor markers Biochemical markers Urine analysis |
Issue Date: | 12-Jan-2016 |
Publisher: | Impact Journals |
Abstract: | Extracellular vesicles (EV) are emerging structures with promising properties for intercellular communication. In addition, the characterization of EV in biofluids is an attractive source of non-invasive diagnostic, prognostic and predictive biomarkers. Here we show that urinary EV (uEV) from prostate cancer (PCa) patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH). Importantly, transcriptomics characterization of uEVs led us to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients. Tissue and cell line analysis strongly suggested that the status of CDH3 in uEVs is a distal reflection of changes in the expression of this cadherin in the prostate tumor. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. Our results reveal that uEVs could represent a non-invasive tool to inform about the molecular alterations in PCa. |
Note: | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.6899 |
It is part of: | Oncotarget, 2016, vol. 7, num. 6, p. 6835-6846 |
URI: | http://hdl.handle.net/2445/114213 |
Related resource: | https://doi.org/10.18632/oncotarget.6899 |
ISSN: | 1949-2553 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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