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DC Field | Value | Language |
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dc.contributor.author | Pastor, Lucía | - |
dc.contributor.author | Casellas, Aina | - |
dc.contributor.author | Carrillo, Jorge | - |
dc.contributor.author | Alonso, Sergi | - |
dc.contributor.author | Parker, Erica | - |
dc.contributor.author | Fuente Soro, Laura | - |
dc.contributor.author | Jairoce, Chenjerai | - |
dc.contributor.author | Mandomando, Inácio | - |
dc.contributor.author | Blanco, Julià | - |
dc.contributor.author | Naniche, Denise | - |
dc.date.accessioned | 2017-09-26T11:27:41Z | - |
dc.date.available | 2017-09-26T11:27:41Z | - |
dc.date.issued | 2017-08-14 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/115803 | - |
dc.description.abstract | Acute HIV infection (AHI) is the period prior to seroconversion characterized by high viral replication, hyper-transmission potential and commonly, non-specific febrile illness. AHI detection requires HIV-RNA viral load (VL) determination, which has very limited access in low-income countries due to restrictive costs and implementation constraints. We sought to identify a biomarker that could enable AHI diagnosis in scarce-resource settings, and to evaluate the feasibility of its implementation. HIV-seronegative adults presenting at the Manhica District Hospital, Mozambique, with reported-fever were tested for VL. Plasma levels of 49 inflammatory biomarkers from AHI (n = 61) and non-HIV infected outpatients (n = 65) were determined by Luminex and ELISA. IP-10 demonstrated the best predictive power for AHI detection (AUC = 0.88 [95%CI 0.80-0.96]). A cut-off value of IP-10 >/= 161.6 pg/mL provided a sensitivity of 95.5% (95%CI 85.5-99.5) and a specificity of 76.5% (95%CI 62.5-87.2). The implementation of an IP-10 screening test could avert from 21 to 84 new infections and save from US$176,609 to US$533,467 to the health system per 1,000 tested patients. We conclude that IP-10 is an accurate biomarker to screen febrile HIV-seronegative individuals for subsequent AHI diagnosis with VL. Such an algorithm is a cost-effective strategy to prevent disease progression and a substantial number of further HIV infections. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1038/s41598-017-08218-0 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, num. 1, p. 8104 | - |
dc.relation.uri | http://dx.doi.org/10.1038/s41598-017-08218-0 | - |
dc.rights | cc by (c) Pastor et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Cribratge | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Medical screening | - |
dc.title | IP-10 Levels as an Accurate Screening Tool to Detect Acute HIV Infection in Resource-Limited Settings | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-09-06T18:00:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28808319 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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pastor2017_2663.pdf | 2.85 MB | Adobe PDF | View/Open |
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