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http://hdl.handle.net/2445/116351
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DC Field | Value | Language |
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dc.contributor.author | Stanzani, Elisabetta | - |
dc.contributor.author | Martínez Soler, Fina | - |
dc.contributor.author | Martín Mateos, Teresa | - |
dc.contributor.author | Vidal, Noemí | - |
dc.contributor.author | Villanueva Garatachea, Alberto | - |
dc.contributor.author | Pujana Genestar, M. Ángel | - |
dc.contributor.author | Serra-Musach, Jordi | - |
dc.contributor.author | Iglesia, Núria de la | - |
dc.contributor.author | Giménez Bonafé, Pepita | - |
dc.contributor.author | Tortosa i Moreno, Avelina | - |
dc.date.accessioned | 2017-10-09T12:13:55Z | - |
dc.date.available | 2017-10-09T12:13:55Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116351 | - |
dc.description.abstract | Glioblastoma (GBM) still remains an incurable disease being radiotherapy (RT) the mainstay treatment. Glioblastoma intra-tumoral heterogeneity and GlioblastomaInitiating Cells (GICs) challenge the design of effective therapies. We investigated GICs and non-GICs response to RT in a paired in-vitro model and addressed molecular programs activated in GICs after RT. Established GICs heterogeneously expressed several GICs markers and displayed a mesenchymal signature. Upon fractionated RT, GICs reported higher radioresistance compared to non-GICs and showed lower α- and β-values, according to the Linear Quadratic Model interpretation of the survival curves. Moreover, a significant correlation was observed between GICs radiosensitivity and patient disease-free survival. Transcriptome analysis of GICs after acquisition of a radioresistant phenotype reported significant activation of Proneural-to-Mesenchymal transition (PMT) and pro-inflammatory pathways, being STAT3 and IL6 the major players. Our findings support a leading role of mesenchymal GICs in defining patient response to RT and provide the grounds for targeted therapies based on the blockade of inflammatory pathways to overcome GBM radioresistance. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Impact Journals | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.18632/oncotarget.18363 | - |
dc.relation.ispartof | Oncotarget, 2017, vol. 8, num. 43, p. 73640-73653 | - |
dc.relation.uri | https://doi.org/10.18632/oncotarget.18363 | - |
dc.rights | cc-by (c) Stanzani, Elisabetta et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Glioma | - |
dc.subject.classification | Tumors cerebrals | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Radioteràpia | - |
dc.subject.other | Gliomas | - |
dc.subject.other | Brain tumors | - |
dc.subject.other | Stem cells | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Radiotherapy | - |
dc.title | Radioresistance of mesenchymal glioblastoma initiating cells correlates with patient outcome and is associated with activation of inflammatory program | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 671378 | - |
dc.date.updated | 2017-10-09T12:13:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29088733 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Infermeria Fonamental i Clínica) |
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File | Description | Size | Format | |
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671378.pdf | 5.36 MB | Adobe PDF | View/Open |
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