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http://hdl.handle.net/2445/116597
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DC Field | Value | Language |
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dc.contributor.author | Martínez Mármol, Ramón | - |
dc.contributor.author | Barneda Zahonero, Bruna | - |
dc.contributor.author | Soto del Cerro, David | - |
dc.contributor.author | Andrés, Rosa María | - |
dc.contributor.author | Coccia, Elena | - |
dc.contributor.author | Gasull Casanova, Xavier | - |
dc.contributor.author | Planells Ferrer, Laura | - |
dc.contributor.author | Moubarak, Rana S. | - |
dc.contributor.author | Soriano García, Eduardo | - |
dc.contributor.author | Comella i Carnicé, Joan Xavier, 1963- | - |
dc.date.accessioned | 2017-10-13T14:03:32Z | - |
dc.date.available | 2017-10-13T14:03:32Z | - |
dc.date.issued | 2016-10-21 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116597 | - |
dc.description.abstract | Caspases have recently emerged as key regulators of axonal pruning and degeneration and of long-term depression (LTD), a long-lasting form of synaptic plasticity. However, the mechanism underlying these functions remains unclear. In this context, XIAP has been shown to modulate these processes. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. Additionally, we demonstrate that the participation of FAIM-L in these two processes is dependent on its capacity to stabilize XIAP protein levels. Our data reveal FAIM-L as a regulator of axonal degeneration and synaptic plasticity. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep35775 | - |
dc.relation.ispartof | Scientific Reports, 2016, vol. 6, p. 35775 | - |
dc.relation.uri | https://doi.org/10.1038/srep35775 | - |
dc.rights | cc-by (c) Martínez-Mármol, Ramón et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Apoptosi | - |
dc.subject.classification | Malalties del sistema nerviós | - |
dc.subject.other | Apoptosis | - |
dc.subject.other | Nervous system Diseases | - |
dc.title | FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 666959 | - |
dc.date.updated | 2017-10-13T14:03:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27767058 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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666959.pdf | 3.24 MB | Adobe PDF | View/Open |
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