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http://hdl.handle.net/2445/116822
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DC Field | Value | Language |
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dc.contributor.author | Vivas, M. | - |
dc.contributor.author | Force Sanmartín, Enriqueta | - |
dc.contributor.author | El Haj Hidalgo, Cristina | - |
dc.contributor.author | Tubau, Fe | - |
dc.contributor.author | Ariza Cardenal, Javier | - |
dc.contributor.author | Cabellos Mínguez, Ma. Carmen | - |
dc.date.accessioned | 2017-10-19T16:59:10Z | - |
dc.date.available | 2017-10-19T16:59:10Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.issn | 1684-1182 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116822 | - |
dc.description.abstract | Background/Purpose: To measure the inflammatory response in terms of tumor necrosis factor-alpha (TNF-α) levels in cerebrospinal fluid (CSF), using bacteriolytic versus nonbacteriolytic antibiotic therapy and adjunctive treatment with dexamethasone in an experimental rabbit model of pneumococcal meningitis. Methods: In a rabbit model of pneumococcal meningitis, we tested CSF TNF-α levels in several samples from rabbits infected with the HUB 2349 strain and treated with ceftriaxone 100 mg/kg/d, ceftriaxone plus vancomycin 30 mg/kg/d, or daptomycin at 15 mg/kg or 25 mg/kg. Daptomycin schedules were compared with the same doses in combination with dexamethasone at 0.125 mg/kg every 12 hours over a 26-hour period. Results: The ceftriaxone group had the highest levels of TNF-α. TNF-α levels were significantly higher after ceftriaxone administration than in both daptomycin groups. The high-dose daptomycin group presented the lowest inflammatory levels in CSF samples. Adjunctive treatment with dexamethasone in this group modulated the inflammatory response, bringing down CSF TNF-α levels. Conclusion: CSF TNF-α levels were significantly lower in rabbits treated with daptomycin than in rabbits treated with ceftriaxone. Daptomycin avoided the inflammatory peak after administration observed in ceftriaxone-treated rabbits. The use of daptomycin plus dexamethasone achieved a significantly larger reduction in CSF TNF-α levels. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jmii.2015.07.014 | - |
dc.relation.ispartof | Journal of Microbiology Immunology and Infection, 2017, vol. 50, num. 4, p. 435-439 | - |
dc.relation.uri | https://doi.org/10.1016/j.jmii.2015.07.014 | - |
dc.rights | cc-by-nc-nd (c) Taiwan Society of Microbiology, 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Pneumococs | - |
dc.subject.classification | Meningitis | - |
dc.subject.classification | Tumors | - |
dc.subject.classification | Antibiòtics betalactàmics | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Streptococcus pneumonia | - |
dc.subject.other | Meningitis | - |
dc.subject.other | Tumors | - |
dc.subject.other | Beta lactam antibiotics | - |
dc.title | Experimental study of cerebrospinal fluid tumor necrosis factor-alpha release in penicillin- and cephalosporin-resistant pneumococcal meningitis treated with different antibiotic schedules | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 658892 | - |
dc.date.updated | 2017-10-19T16:59:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26452467 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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658892.pdf | 353.17 kB | Adobe PDF | View/Open |
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