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DC Field | Value | Language |
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dc.contributor.author | May, Margaret T. | - |
dc.contributor.author | Vehreschild, Jörg Janne | - |
dc.contributor.author | Trickey, Adam | - |
dc.contributor.author | Obel, Niels | - |
dc.contributor.author | Reiss, Peter | - |
dc.contributor.author | Bonnet, Fabrice | - |
dc.contributor.author | Mary-Krause, Murielle | - |
dc.contributor.author | Samji, Hasina | - |
dc.contributor.author | Cavassini, Matthias | - |
dc.contributor.author | Gill, Michael John | - |
dc.contributor.author | Shepherd, Leah C. | - |
dc.contributor.author | Crane, Heidi M. | - |
dc.contributor.author | D'Arminio Monforte, Antonella | - |
dc.contributor.author | Burkholder, Greer A. | - |
dc.contributor.author | Johnson, Margaret M. | - |
dc.contributor.author | Sobrino Vegas, Paz | - |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) | - |
dc.contributor.author | Zangerle, Robert | - |
dc.contributor.author | Justice, Amy C. | - |
dc.contributor.author | Sterling, Timothy R. | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Sterne, Jonathan A. C. | - |
dc.date.accessioned | 2017-10-23T13:36:10Z | - |
dc.date.available | 2017-10-23T13:36:10Z | - |
dc.date.issued | 2016-03-29 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116934 | - |
dc.description.abstract | BACKGROUND: CD4 count at start of combination antiretroviral therapy (ART) is strongly associated with short-term survival, but its association with longer-term survival is less well characterized. METHODS: We estimated mortality rates (MRs) by time since start of ART (<0.5, 0.5-0.9, 1-2.9, 3-4.9, 5-9.9, and ≥10 years) among patients from 18 European and North American cohorts who started ART during 1996-2001. Piecewise exponential models stratified by cohort were used to estimate crude and adjusted (for sex, age, transmission risk, period of starting ART [1996-1997, 1998-1999, 2000-2001], and AIDS and human immunodeficiency virus type 1 RNA at baseline) mortality rate ratios (MRRs) by CD4 count at start of ART (0-49, 50-99, 100-199, 200-349, 350-499, ≥500 cells/µL) overall and separately according to time since start of ART. RESULTS: A total of 6344 of 37 496 patients died during 359 219 years of follow-up. The MR per 1000 person-years was 32.8 (95% confidence interval [CI], 30.2-35.5) during the first 6 months, declining to 16.0 (95% CI, 15.4-16.8) during 5-9.9 years and 14.2 (95% CI, 13.3-15.1) after 10 years' duration of ART. During the first year of ART, there was a strong inverse association of CD4 count at start of ART with mortality. This diminished over the next 4 years. The adjusted MRR per CD4 group was 0.97 (95% CI, .94-1.00; P = .054) and 1.02 (95% CI, .98-1.07; P = .32) among patients followed for 5-9.9 and ≥10 years, respectively. CONCLUSIONS: After surviving 5 years of ART, the mortality of patients who started ART with low baseline CD4 count converged with mortality of patients with intermediate and high baseline CD4 counts. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/cid/ciw183 | - |
dc.relation.ispartof | Clinical Infectious Diseases, 2016, vol. 62, num. 12, p. 1571-1572 | - |
dc.relation.uri | https://doi.org/10.1093/cid/ciw183 | - |
dc.rights | cc-by (c) May, Margaret T. et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | Morbiditat | - |
dc.subject.classification | Limfòcits | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | Morbidity | - |
dc.subject.other | Lymphocytes | - |
dc.title | Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment: collaborative cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 660553 | - |
dc.date.updated | 2017-10-23T13:36:10Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260694/EU//EUROCOORD | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27025828 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
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