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http://hdl.handle.net/2445/116945
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DC Field | Value | Language |
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dc.contributor.author | Manzano Salgado, Cyntia B. | - |
dc.contributor.author | Casas, Maribel | - |
dc.contributor.author | López Espinosa, Maria-Jose | - |
dc.contributor.author | Ballester, Ferran | - |
dc.contributor.author | Iñiguez, Carmen | - |
dc.contributor.author | Martínez, David | - |
dc.contributor.author | Romaguera, Dora | - |
dc.contributor.author | Fernández Barrés, Silvia | - |
dc.contributor.author | Santa Marina, Loreto | - |
dc.contributor.author | Basterretxea, Mikel | - |
dc.contributor.author | Schettgen, Thomas | - |
dc.contributor.author | Valvi, Damaskini | - |
dc.contributor.author | Vioque, Jesús | - |
dc.contributor.author | Sunyer Deu, Jordi | - |
dc.contributor.author | Vrijheid, Martine | - |
dc.date.accessioned | 2017-10-23T13:59:13Z | - |
dc.date.available | 2017-10-23T13:59:13Z | - |
dc.date.issued | 2017-09-20 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116945 | - |
dc.description.abstract | Background: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. Objectives: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score. Methods: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n≈1,000). At age 4, we calculated the age-, sex-, and region-specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n=627). At age 4, we calculated a CM-risk score (n=386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDL-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometabolic risk at age 4. Results: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL, respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, β=0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (β=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. Conclusions: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Environmental Health Perspectives (eph) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1289/EHP1330 | - |
dc.relation.ispartof | Environmental Health Perspectives, 2017, vol. 125, num. 9, p.097018 | - |
dc.relation.uri | http://dx.doi.org/10.1289/EHP1330 | - |
dc.rights | cc by (c) Manzano et. al, 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Higiene ambiental | - |
dc.subject.classification | Medicina prenatal | - |
dc.subject.other | Environmental health | - |
dc.subject.other | Prenatal medicine | - |
dc.title | Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-10-18T18:01:14Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/282957/EU//DENAMIC | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28934720 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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manzano-salgado2017_2702.pdf | 394.41 kB | Adobe PDF | View/Open |
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