Title: | Cohort Profile: Pregnancy And Childhood Epigenetics (PACE)
Consortium |
Author: | Felix, Janine F. Joubert, Bonnie R. Baccarelli, Andrea A. Sharp, Gemma C. Almqvist, Catarina Annesi-Maesano, Isabella Arshad, Hasan Baiz, Nour Bakermans-Kranenburg, Marian J. Bakulski, Kelly M. Binder, Elisabeth B. Plusquin, Michelle Tiemeier, Henning Raikkonen, Katri Rzehak, Peter Wang, Pei Reese, Sarah E. Reischl, Eva Richiardi, Lorenzo Ring, Susan M. Schwartz, David A. Wiemels, Joseph L. Taylor, Jack A. Yousefi, Paul Sebert, Sylvain Snieder, Harold Sorensen, Thorkild I. A. Starling, Anne P. Ullemar, Vilhelmina Zhang, Weiming Vafeiadi, Marina Bouchard, Luigi Brunekreef, Bert Van Ijzendoorn, Marinus H. Vonk, Judith M. Vriens, Annette Vrijheid, Martine Wilcox, Allen J. Zhang, Hongmei Czamara, Darina Wright, Rosalind J. Xu, Cheng-Jian Xu, Zongli Yang, Ivana V. Zhao, Shanshan Davey Smith, George Breton, Carrie V. Everson, Todd M. Agha, Golareh Relton, Caroline L. Jaddoe, Vincent W. London, Stephanie J. Brunst, Kelly J. Fallin, M. Daniele Burchard, Esteban G. Dabelea, Dana Gonseth, Semira Bustamante Pineda, Mariona Chatzi, Leda Cheng Munthe-Kaas, Monica Corpeleijn, Eva De Boever, Patrick Falahi, Fahimeh Holloway, John W. Duijts, Liesbeth Dwyer, Terence Eng, Celeste Eskenazi, Brenda Farchi, Sara Hu, Donglei Fernandez, Mariana F. Karagas, Margaret R. Gao, Lu Gaunt, Tom R. Ghantous, Akram Gillman, Matthew W. Grote, Veit Karmaus, Wilfried Gruzieva, Olena Hoyo, Cathrine Ladd-Acosta, Christine Haberg, Siri E. Herceg, Zdenko Hivert, Marie-France Holland, Nina Huang, Rae-Chi Karlsson, Robert Magnus, Per Huen, Karen Jarvelin, Marjo-Riitta Jima, Dereje D. Just, Allan C. Kechris, Katerina J. Marsit, Carmen J. Kere, Juha Nistico, Lorenza Kogevinas, Manolis Koletzko, B. (Berthold) Koppelman, Gerard H. Kupers, Leanne K. Lahti, Jari Nordlund, Bjorn Lambrechts, Nathalie Maguire, Rachel L. Pizzi, Costanza Langie, Sabine A. S. Lie, Rolv T. Liu, Andrew H. Magnus, Maria C. McArdle, Wendy Nohr, Ellen Aagard Roy, Ritu Melén, Erik Melton, Phillip E. Murphy, Susan K. Nawrot, Tim S. Nystad, Wenche Schoeters, Greet Oh, Sam S. Sunyer Deu, Jordi Oken, Emily Page, Christian Magnus Perron, Patrice Pershagen, Göran |
Keywords: | Epigenètica Embaràs Epigenetics Pregnancy |
Issue Date: | 13-Sep-2017 |
Publisher: | Oxford University Press |
Abstract: | Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA sequence, but can influence its function. Currently, DNA methylation is the most studied epigenetic phenomenon in large populations. It entails the binding of a methyl group, mainly to positions in genomic DNA where a cytosine is located next to a guanine, a cytosine-phosphate-guanine (CpG) site (Figure 1). DNA methylation at CpG sites can influence gene expression by altering the DNA’s three-dimensional structure and interacting with methyl-binding proteins, consequently affecting the binding of the gene transcription and chromatin-modifying machinery. There are approximately 28 million CpG sites in the human genome. DNA methylation is a dynamic process that can be influenced by genetic factors, as well as by environmental factors such as diet, air pollution, toxicants or smoking.1–4 Hence, DNA methylation may be seen as linking the genome to the environment with respect to health and disease. Early development is a period of profound changes in DNA methylation and may, as such, be a critical period for environmentally-induced DNA methylation changes.4 Hence, this period is of specific interest for DNA methylation studies in relation to specific exposures and long-term health outcomes |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1093/ije/dyx190 |
It is part of: | International Journal of Epidemiology, 2017, vol. , num. , p.
Ahead of print |
URI: | http://hdl.handle.net/2445/117488 |
Related resource: | http://dx.doi.org/10.1093/ije/dyx190 |
ISSN: | 0300-5771 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Publicacions de projectes de recerca finançats per la UE
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