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http://hdl.handle.net/2445/117492
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DC Field | Value | Language |
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dc.contributor.author | Selinski, Silvia | - |
dc.contributor.author | Blaszkewicz, Meinolf | - |
dc.contributor.author | Ickstadt, Katja | - |
dc.contributor.author | Gerullis, Holger | - |
dc.contributor.author | Otto, Thomas | - |
dc.contributor.author | Roth, Emanuel | - |
dc.contributor.author | Volkert, Frank | - |
dc.contributor.author | Ovsiannikov, Daniel | - |
dc.contributor.author | Moormann, Oliver | - |
dc.contributor.author | Banfi, Gergely | - |
dc.contributor.author | Nyirady, Peter | - |
dc.contributor.author | Vermeulen, Sita H. | - |
dc.contributor.author | Garcia Closas, Montserrat | - |
dc.contributor.author | Figueroa, Jonine D. | - |
dc.contributor.author | Johnson, Alison | - |
dc.contributor.author | Karagas, Margaret R. | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.contributor.author | Malats, Núria | - |
dc.contributor.author | Schwenn, Molly | - |
dc.contributor.author | Silverman, Debra T. | - |
dc.contributor.author | Koutros, Stella | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Kiemeney, Lambertus A. L. M. | - |
dc.contributor.author | Hengstler, Jan G. | - |
dc.contributor.author | Golka, Klaus | - |
dc.date.accessioned | 2017-11-07T14:27:07Z | - |
dc.date.available | 2017-11-07T14:27:07Z | - |
dc.date.issued | 2017-09-27 | - |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | http://hdl.handle.net/2445/117492 | - |
dc.description.abstract | Little is known whether genetic variants identified in genome-wide association studies interact to increase bladder cancer risk. Recently, we identified two- and three-variant combinations associated with a particular increase of bladder cancer risk in a urinary bladder cancer case-control series (IfADo, 1501 cases, 1565 controls). In an independent case-control series (Nijmegen Bladder Cancer Study, NBCS, 1468 cases, 1720 controls) we confirmed these two- and three-variant combinations. Pooled analysis of the two studies as discovery group (IfADo-NBCS) resulted in sufficient statistical power to test up to four-variant combinations by a logistic regression approach. The New England and Spanish Bladder Cancer Studies (2080 cases and 2167 controls) were used as a replication series. Twelve previously identified risk variants were considered.The strongest four-variant combination was obtained in never smokers. The combination of rs1014971[AA] near APOBEC3A and CBX6, SLC14A1 exon SNP rs1058396[AG,GG], UGT1A intron SNP rs11892031[AA], and rs8102137[CC,CT] near CCNE resulted in an unadjusted odds ratio of 2.59 (95% CI = 1.93-3.47; P = 1.87x10-10), while the individual variant odds ratios ranged only between 1.11-1.30. The combination replicated in the New England and Spanish bladder Cancer Studies (ORunadjusted=1.60, 95% CI = 1.10-2.33; P = 0.013). The four-variant combination is relatively frequent, with 25% in never smoking cases and 11% in never smoking controls (total study group: 19% cases, 14% controls). In conclusion, we show that four high risk variants can statistically interact to confer increased bladder cancer risk particularly in never smokers. | - |
dc.format.extent | Ahead of print | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1093/carcin/bgx102 | - |
dc.relation.ispartof | Carcinogenesis, 2017, vol. , num. , p. Ahead of print | - |
dc.relation.uri | http://dx.doi.org/10.1093/carcin/bgx102 | - |
dc.rights | (c) Oxford University Press, 2017 | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Aparell genitourinari | - |
dc.subject.classification | Oncologia | - |
dc.subject.other | Genitourinary organs | - |
dc.subject.other | Oncology | - |
dc.title | Identification and replication of the interplay of four genetic high risk variants for urinary bladder cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-11-01T19:00:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29028944 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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selinski2017_2733.pdf | 563.89 kB | Adobe PDF | View/Open |
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