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http://hdl.handle.net/2445/117493
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DC Field | Value | Language |
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dc.contributor.author | Gupta, Himanshu | - |
dc.contributor.author | Matambisso, Gloria | - |
dc.contributor.author | Galatas, Beatriz | - |
dc.contributor.author | Cisteró, Pau | - |
dc.contributor.author | Nhamussua, Lidia | - |
dc.contributor.author | Simone, Wilson | - |
dc.contributor.author | Cunningham, Jane | - |
dc.contributor.author | Rabinovich, Regina | - |
dc.contributor.author | Alonso, Pedro | - |
dc.contributor.author | Saute, Francisco | - |
dc.contributor.author | Aide, Pedro Carlos Paulino | - |
dc.contributor.author | Mayor Aparicio, Alfredo Gabriel | - |
dc.date.accessioned | 2017-11-07T14:29:42Z | - |
dc.date.available | 2017-11-07T14:29:42Z | - |
dc.date.issued | 2017-10-16 | - |
dc.identifier.issn | 1475-2875 | - |
dc.identifier.uri | http://hdl.handle.net/2445/117493 | - |
dc.description.abstract | BACKGROUND: Malaria programmes use Plasmodium falciparum histidine-rich protein-2 (PfHRP2) based rapid diagnostic tests (RDTs) for malaria diagnosis. The deletion of this target antigen could potentially lead to misdiagnosis, delayed treatment and continuation of active transmission. METHODS: Plasmodium falciparum isolates (n = 1162) collected in Southern Mozambique were assessed by RDTs, microscopy and/or 18SrRNA qPCR. pfhrp2 and pfhrp3 deletions were investigated in isolates from individuals who were negative by RDT but positive by microscopy and/or qPCR (n = 69) using gene-specific PCRs, with kelch13 PCR as the parasite DNA control. RESULTS: Lack of pfhrp2 PCR amplification was observed in one of the 69 isolates subjected to molecular analysis [1.45% (95% CI 0.3-7.8%)]. CONCLUSIONS: The low prevalence of pfhrp2 deletions suggests that RDTs will detect the vast majority of the P. falciparum infections. Nevertheless, active surveillance for changing deletion frequencies is required. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-017-2061-z | - |
dc.relation.ispartof | Malaria Journal, 2017, vol. 16, num. 1, p. 416 | - |
dc.relation.uri | http://dx.doi.org/10.1186/s12936-017-2061-z | - |
dc.rights | cc by (c) Gupta et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Moçambic | - |
dc.subject.other | Malaria | - |
dc.subject.other | Mozambique | - |
dc.title | Molecular surveillance of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum isolates from Mozambique | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-11-01T19:00:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29037193 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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gupta2017_2737.pdf | 1.12 MB | Adobe PDF | View/Open |
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