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DC Field | Value | Language |
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dc.contributor.author | Pastor, Lucía | - |
dc.contributor.author | Casellas, Aina | - |
dc.contributor.author | Rupérez, María | - |
dc.contributor.author | Carrillo, Jorge | - |
dc.contributor.author | Maculuve, Sónia Amós | - |
dc.contributor.author | Jairoce, Chenjerai | - |
dc.contributor.author | Paredes, Roger | - |
dc.contributor.author | Blanco, Julià | - |
dc.contributor.author | Naniche, Denise | - |
dc.date.accessioned | 2017-11-10T13:43:07Z | - |
dc.date.available | 2017-11-10T13:43:07Z | - |
dc.date.issued | 2017-10-30 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | http://hdl.handle.net/2445/117626 | - |
dc.description.abstract | Background: Achieving effective antiretroviral treatment (ART) monitoring is a key determinant to ensure viral suppression and reach the UNAIDS 90-90-90 targets. The gold standard for detecting virological failure is plasma human immunodeficiency virus (HIV) RNA (viral load [VL]) testing; however, its availability is very limited in low-income countries due to cost and operational constraints. Methods: HIV-1-infected adults on first-line ART attending routine visits at the Manhica District Hospital, Mozambique, were previously evaluated for virologic failure. Plasma levels of interferon-gamma-inducible protein 10 (IP-10) were quantified by enzyme-linked immunosorbent assay. Logistic regression was used to build an IP-10-based model able to identify individuals with VL >150 copies/mL. From the 316 individuals analyzed, 253 (80%) were used for model training and 63 (20%) for validation. Receiver operating characteristic curves were employed to evaluate model prediction. Results: From the individuals included in the training set, 34% had detectable VL. Mean age was 41 years, 70% were females, and median time on ART was 3.4 years. IP-10 levels were significantly higher in subjects with detectable VL (108.2 pg/mL) as compared to those with undetectable VL (38.0 pg/mL) (P < .0001, U test). IP-10 univariate model demonstrated high classification performance (area under the curve = 0.85 [95% confidence interval {CI}, .80-.90]). Using a cutoff value of IP-10 >/=44.2 pg/mL, the model identified detectable VL with 91.9% sensitivity (95% CI, 83.9%-96.7%) and 59.9% specificity (95% CI, 52.0%-67.4%), values confirmed in the validation set. Conclusions: IP-10 is an accurate biomarker to screen individuals on ART for detectable viremia. Further studies should evaluate the benefits of IP-10 as a triage approach to monitor ART in resource-limited settings. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1093/cid/cix600 | - |
dc.relation.ispartof | Clinical Infectious Diseases, 2017, vol.65 , num.10 , p. 1670-1675 | - |
dc.relation.uri | http://dx.doi.org/10.1093/cid/cix600 | - |
dc.rights | cc by (c) Pastor et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Immunitat cel·lular | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Cellular immunity | - |
dc.title | Interferon-gamma-Inducible Protein 10 (IP-10) as a Screening Tool to Optimize Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-11-01T19:00:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29020145 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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File | Description | Size | Format | |
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pastor2017_2730.pdf | 245.43 kB | Adobe PDF | View/Open |
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