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Title: | Monte Carlo simulation of super-selective supramolecular polymers on cell membranes |
Author: | Terradellas Igual, Adrià |
Director/Tutor: | Pagonabarraga Mora, Ignacio Albertazzi, Lorenzo |
Keywords: | Polímers Membranes cel·lulars Mètode de Montecarlo Treballs de fi de grau Polymers Cell membranes Monte Carlo method Bachelor's theses |
Issue Date: | Jun-2017 |
Abstract: | Super-selectivity is a key challenge to design multivalent nano-entities that can bind ideally in a binary response \on-off"to selective receptor-concentration targeting. In this study, it is simulated a 2D canonical ensemble Monte Carlo to sample semiflexible polymer chains conformations with determined percentage of functionalized monomers, which are capable to be bound to a receptor. In addition, it is quantized the adsorption of polymers to cell membranes and analyzed their behaviour depending on potentially selective sources. In closing, it is simulated a novel self-assembled nanofiber to analyze its therapeutic potential for drug delivery. |
Note: | Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2017, Tutor: Ignacio Pagonabarraga, Co-tutor: Lorenzo Albertazzi |
URI: | http://hdl.handle.net/2445/117758 |
Appears in Collections: | Treballs Finals de Grau (TFG) - Física |
Files in This Item:
File | Description | Size | Format | |
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Terradellas Igual Adrià.pdf | 634.83 kB | Adobe PDF | View/Open |
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