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http://hdl.handle.net/2445/118182
Title: | A role for caspase-8 and TRAIL-R2/DR5 in ER-stress induced apoptosis |
Author: | Muñoz Pinedo, Cristina López Rivas, Abelardo |
Keywords: | Proteïnes Apoptosi Proteins Apoptosis |
Issue Date: | 6-Oct-2017 |
Publisher: | Nature Publishing Group |
Abstract: | Glab and colleagues examine in a recent paper apoptosis induced by some driverss of endoplasmic reticulum (ER) stress. They conclude that in contrast to a previously published report2 , DR5/TRAIL-R2 and caspase-8 are universally dispensable in ER stress-induced apoptosis. We argue here that their own data and other published reports indicate that in many models, DR5 and/or caspase-8 are essential players in apoptosis mediated by the unfolded protein response (UPR), upon chronic ER stress. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1038/cdd.2017.155 |
It is part of: | Cell Death & Differentiation, 2017, num. 1 October |
URI: | http://hdl.handle.net/2445/118182 |
Related resource: | http://dx.doi.org/10.1038/cdd.2017.155 |
ISSN: | 1476-5403 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Muñoz-Pinedo_2017.pdf | 256.17 kB | Adobe PDF | View/Open |
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