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http://hdl.handle.net/2445/118849
Title: | Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery |
Author: | Oller Salvia, Benjamí Sánchez Navarro, Macarena Giralt Lledó, Ernest Teixidó Turà, Meritxell |
Keywords: | Pèptids Sistema nerviós central Barrera hematoencefàlica Peptides Central nervous system Blood-brain barrier |
Issue Date: | 7-Sep-2016 |
Publisher: | Royal Society of Chemistry |
Abstract: | Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available. Although the blood-brain barrier (BBB) prevents most drugs from reaching their targets, molecular vectors - known as BBB shuttles - offer great promise to safely overcome this formidable obstacle. In recent years, peptide shuttles have received growing attention because of their lower cost, reduced immunogenicity, and higher chemical versatility than traditional Trojan horse antibodies and other proteins. |
Note: | Reproducció del document publicat a: https://doi.org/10.1039/C6CS00076B |
It is part of: | Chemical Society Reviews, 2016, vol. 45, num. 17, p. 4690-4707 |
URI: | http://hdl.handle.net/2445/118849 |
Related resource: | https://doi.org/10.1039/C6CS00076B |
ISSN: | 0306-0012 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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