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http://hdl.handle.net/2445/118923
Title: | GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma |
Author: | Moreno Monasterio, Marta Pedrosa, Leire Paré Brunet, Laia Pineda, Estela Bejarano, Leire Martínez Soler, Fina Balasubramaniyan, Veerakumar Ezhilarasan, Ravesanker Kallarackal, Naveen Kim, Sung-Hak Wang, Jia Audia, Alessandra Conroy, Siobhan Marín Aguilera, Mercedes Ribalta Farrés, Teresa María Pujol Farré, Teresa Herreros Martínez, Antonio Tortosa i Moreno, Avelina Mira, Helena Alonso, Marta M. Gómez-Manzano, Candelaria Graus Ribas, Francesc Sulman, Erik P. Piao, Xianhua Nakano, Ichiro Prat Aparicio, Aleix Bhat, Krishna P. Iglesia, Núria de la |
Keywords: | Glioma Tumors Radioteràpia Gliomas Tumors Radiotherapy |
Issue Date: | 21-Nov-2017 |
Publisher: | Elsevier |
Abstract: | A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.celrep.2017.10.083 |
It is part of: | Cell Reports, 2017, vol. 21, num. 8, p. 2183-2197 |
URI: | http://hdl.handle.net/2445/118923 |
Related resource: | https://doi.org/10.1016/j.celrep.2017.10.083 |
ISSN: | 2211-1247 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (Infermeria Fonamental i Clínica) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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