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Título: Impact of switching from lopinavir/ritonavir to atazanavir/ritonavir on body fat redistribution in virologically suppressed HIV-infected adults
Autor: Ferrer, Elena
Río, Luis del
Martínez Chamorro, Esteban José
Curto, J. J. (Jorge Juan)
Domingo, Pere (Domingo Pedrol)
Ribera, Esteban
Negredo, Eugènia
Rosales, Joaquín
Saumoy, Maria
Ordóñez, J. (Jordi), 1952-
Gatell, José M.
Podzamczer Palter, Daniel
Materia: VIH (Virus)
Antiretrovirals
Infeccions per VIH
Obesitat
Teixit adipós
HIV (Viruses)
Antiretroviral agents
HIV infections
Obesity
Adipose tissues
Fecha de publicación: 4-oct-2011
Publicado por: Mary Ann Liebert
Resumen: Changes in body fat distribution in virologically suppressed HIV-infected patients switching from lopinavir/ritonavir (LPV/r) to atazanavir/ritonavir (ATV/r) were assessed. A prospective comparative study was conducted of 37 patients receiving LPV/r regimens switching to ATV/r with 46 patients continuing with LPV/r. Body composition was assessed with whole-body dual-energy x-ray absorptiometry (DXA). Abdominal CT scans were also performed in a subset of patients. Groups were comparable in baseline demographic, clinical, and anthropometric characteristics. After 12 months, peripheral fat did not change significantly, but an increase in trunk fat was observed only in the ATV/r group (0.87 kg, p = 0.021). The percentage of patients with an increase ≥20% in total fat was 37.8% and 15.2% in the ATV/r and LPV/r groups, respectively (p = 0.018). In the ATV/r group, the increase in trunk fat (9.4%) was significantly higher than in peripheral fat (3.7%) (p = 0.007), leading to a significant increase in fat mass ratio (3.76%, p = 0.028), whereas no significant differences were found among LPV/r patients. CT scans showed that abdominal fat increase corresponded to both visceral (28%, p = 0.008) and subcutaneous fat (42%, p = 0.008). These data suggest that switching from LPV/r to ATV/r is associated with increased trunk fat, both subcutaneous and visceral.
Nota: Reproducció del document publicat a: https://doi.org/10.1089/AID.2010.0254
Es parte de: Aids Research and Human Retroviruses, 2011, vol. 27, num. 10, p. 1061-1065
URI: https://hdl.handle.net/2445/118961
Recurso relacionado: https://doi.org/10.1089/AID.2010.0254
ISSN: 0889-2229
Aparece en las colecciones:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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