Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/118990
Title: | Treatment of Chronic Hepatitis C in HIV-Infected Patients with Interferon α-2b Plus Ribavirin |
Author: | Pérez-Olmeda, Mayte Soriano, Vincent Asensi, Victor Morales, Dolores Romero, Miriam Ochoa, Anna Sánchez-Montero, Fausto Santín Cerezales, Miguel Guardiola, Josep Blanch, Jesús Núñez, Marina Jiménez-Nácher, Inmaculada García-Samaniego, Javier HCV/HIV Spanish Study Team |
Keywords: | Hepatitis C Interferó Efecte dels medicaments sobre els microorganismes Medicaments antivírics Infeccions per VIH Hepatitis C Interferon Effect of drugs on microorganisms Antiviral agents HIV infections |
Issue Date: | Dec-2003 |
Publisher: | Mary Ann Liebert |
Abstract: | One hundred six HIV-infected patients with chronic hepatitis C virus (HCV) infection were randomized to receive ribavirin (RBV) 400 mg bid plus interferon α-2b (IFN-α) at two different doses, 3 mU tiw (control arm) or 5 mU daily for the first 6 weeks, followed by 3 mU tiw until completing 6 months of therapy (induction arm). All patients had CD4 counts above 350 cells/μl and 89% were taking antiretroviral therapy. Adverse effects leading to treatment discontinuation occurred in 12.3% of patients, a rate quite similar to that seen in HCV-monoinfected patients. Negative serum HCV-RNA values (<60 IU/ml) were recorded in 24.7% and 35.5% of patients at 3 and 6 months of therapy. However, in the intent-to-treat analysis, sustained response was reached by only 16% of patients (22.4% in the on-treatment analysis). No differences between treatment arms were noticed. Patients with HCV genotypes 2 or 3 had a 7-fold higher response rate than those with HCV genotypes 1 or 4. Therefore, early, end-of-treatment, and sustained response rates are lower in HIV/HCV-coinfected patients treated with RBV/IFN-α combination therapy. Since HCV-related liver disease is currently one of the leading causes of morbidity and mortality among HIV-infected patients, new treatment options are urgently needed for coinfected individuals. |
Note: | Reproducció del document publicat a: https://doi.org/10.1089/088922203771881176 |
It is part of: | Aids Research and Human Retroviruses, 2003, vol. 19, num. 12, p. 1083-1089 |
URI: | http://hdl.handle.net/2445/118990 |
Related resource: | https://doi.org/10.1089/088922203771881176 |
ISSN: | 0889-2229 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
654015.pdf | 162.98 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.