Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/118996
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Phillips, Owen R. | - |
dc.contributor.author | Squitieri, Ferdinando | - |
dc.contributor.author | Sánchez Castañeda, Cristina | - |
dc.contributor.author | Elifani, Francesca | - |
dc.contributor.author | Caltagirone, Carlo | - |
dc.contributor.author | Sabatini, Umberto | - |
dc.contributor.author | Paola, Margherita di | - |
dc.date.accessioned | 2018-01-11T18:25:13Z | - |
dc.date.available | 2018-01-11T18:25:13Z | - |
dc.date.issued | 2014-10-23 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/118996 | - |
dc.description.abstract | White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weighted (iron sensitive) imaging. We collected Pre-HD subjects (n = 25), HD patients (n = 25) and healthy control subjects (n = 50). Results revealed increased axial (AD) and radial diffusivity (RD) and iron levels in Pre-HD subjects compared to controls. Fractional anisotropy decreased between the Pre-HD and HD phase and AD/RD increased and although impairment was pervasive in HD, degeneration occurred in a pattern in Pre-HD. Furthermore, iron levels dropped for HD patients. As increased iron levels are associated with remyelination, the data suggests that Pre-HD subjects attempt to repair damaged deep WM years before symptoms occur but this process fails with disease progression. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0109676 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 10, p. e109676 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0109676 | - |
dc.rights | cc-by (c) Phillips, Owen et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) | - |
dc.subject.classification | Demència | - |
dc.subject.classification | Corea de Huntington | - |
dc.subject.classification | Malalties neurodegeneratives | - |
dc.subject.other | Dementia | - |
dc.subject.other | Huntington's chorea | - |
dc.subject.other | Neurodegenerative Diseases | - |
dc.title | Deep white matter in Huntington's disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 659543 | - |
dc.date.updated | 2018-01-11T18:25:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25340651 | - |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
659543.pdf | 1.19 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License