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Title: The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis
Author: Alonso-Molero, Jéssica
González Donquiles, Carmen
Palazuelos-Calderón, Camilo
Fernández Villa, Tania
Ramos, Elena
Pollán, Marina
Aragonès Sanz, Núria
Llorca Díaz, Javier
Alonso Aguado, Maria Henar
Tardón, Adonina
Amiano, Pilar
Jiménez Moleón, José Juan
Peiró Pérez, Rosana
Capelo Álvarez, Rocío
Molina de la Torre, Antonio José
Gómez Acebo, Inés
Guevara, Marcela
Pérez Gómez, Beatriz
Lope, Virginia
Huerta Castaño, José María
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Moreno Aguado, Víctor
Martín Sánchez, Vicente
Keywords: Càncer colorectal
Cuina mediterrània
Colorectal cancer
Mediterranean cooking
Issue Date: 30-Oct-2017
Publisher: BioMed Central
Abstract: Background: The objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer. Methods: We examined 1087 cases of colorectal cancer and 2409 population controls with available DNA samples from the MCC-Spain study, 2008–2012. Descriptive statistical analyses, and multivariate logistic mixed models were performed. The potential synergistic effect of rs4939827 and the Mediterranean diet pattern was evaluated with logistic regression in different strata of of adherence to the Mediterranean diet and the genotype. Results: High adherence to Mediterrenean diet was statistically significantly associated with colorectal cancer risk. A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51–0. 81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827. Although the decreased risk for the CC genotype was slightly more pronounced in subjects with high adherence to Mediterrenean diet, there was no statistically significant synergistic effect between genotype CC and adherence to the Mediterranean dietary pattern factors. Conclusion: The SMAD7 gene and specifically the allele C could be protective for colorectal cancer. An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC risk. Findings form this study indicate that high adherence to Mediterranean diet pattern has a protective role for CRC cancer probably involving the Tumor Growth Factor- β pathway in this cancer
Note: Reproducció del document publicat a:
It is part of: BMC Medical Genetics, 2017, vol. 18, num. 122
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ISSN: 1471-2350
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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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