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http://hdl.handle.net/2445/119014
Title: | Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. |
Author: | Lee, Seung-Tae Muench, Marcus O. Fomin, Marina E. Xiao, Jianqiao Zhou, Mi Smith, Adam de Martín-Subero, José Ignacio Heath, Simon C. Houseman, E.Andres Roy, Ritu Wrensch, Margaret Wiencke, John K. Metayer, Catherine Wiemels, Joseph L. |
Keywords: | Leucèmia Epigenètica Cèl·lules mare embrionàries Leukemia Epigenetics Embryonic stem cells |
Issue Date: | 11-Mar-2015 |
Publisher: | Oxford University Press |
Abstract: | We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large inter-compartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkv103 |
It is part of: | Nucleic Acids Research, 2015, vol. 43, num. 5, p. 2590-2602 |
URI: | http://hdl.handle.net/2445/119014 |
Related resource: | https://doi.org/10.1093/nar/gkv103 |
ISSN: | 0305-1048 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) |
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