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http://hdl.handle.net/2445/119034| Title: | Exuberant complex metaplastic carcinoma of the breast with sox2 expression: covering the full spectrum of ductal neoplasia of the breast |
| Author: | Sagasta, Amaia Saco, Adela Rodríguez-Carunchio, Leonardo Rull Ortuño, Antonio Ramón Ruiz, Ana Carrió, Ana Falcón Escobedo, Reynaldo Fernández Ruiz, Pedro Luis |
| Keywords: | Càncer de mama Tumors Oncologia Breast cancer Tumors Oncology |
| Issue Date: | 21-Nov-2014 |
| Publisher: | Elsevier España |
| Abstract: | We report a unusual case of a 45-year-old woman with a massive metaplastic carcinoma of the breast with a complex admixture of components including giant pleomorphic cells, sarcomatoid areas, cysts with undifferentiated stratified epithelium, squamous carcinoma foci, high grade comedo-type ductal carcinoma in situ, high grade invasive carcinoma not otherwise specified (NOS) and foci with osseous differentiation. An extensive immunohistochemical panel showed expression of both epithelial and mesenchymal markers. The self-renewal marker SOX2 was expressed in different cell types, which was interpreted as a sign of the pluripotency what can in turn explain the diversity of histologic lineages present in this tumour. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.patol.2014.10.002 |
| It is part of: | Revista Española de Patología, 2014, vol. 48, p. 170-175 |
| URI: | http://hdl.handle.net/2445/119034 |
| Related resource: | https://doi.org/10.1016/j.patol.2014.10.002 |
| ISSN: | 1699-8855 |
| Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 658902.pdf | 4.46 MB | Adobe PDF | View/Open |
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