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http://hdl.handle.net/2445/119078
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DC Field | Value | Language |
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dc.contributor.author | Gupta, Himanshu | - |
dc.contributor.author | Macete, Eusebio Víctor | - |
dc.contributor.author | Bulo, Helder | - |
dc.contributor.author | Salvador, Crizolgo | - |
dc.contributor.author | Warsame, Marian | - |
dc.contributor.author | Carvalho, Eva | - |
dc.contributor.author | Menard, Didier | - |
dc.contributor.author | Ringwald, Pascal | - |
dc.contributor.author | Bassat Orellana, Quique | - |
dc.contributor.author | Enosse, Sonia | - |
dc.contributor.author | Mayor Aparicio, Alfredo Gabriel | - |
dc.date.accessioned | 2018-01-17T16:07:51Z | - |
dc.date.available | 2018-01-17T16:07:51Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1080-6040 | - |
dc.identifier.uri | http://hdl.handle.net/2445/119078 | - |
dc.description.abstract | One of the fundamental steps toward malaria control is the use of antimalarial drugs. The success of antimalarial treatment can be affected by the presence of drug-resistant populations of Plasmodium falciparum. To assess resistance, we used molecular methods to examine 351 P. falciparum isolates collected from 4 sentinel sites in Mozambique for K13, pfmdr1, pfcrt, and pfdhps polymorphisms and for plasmepsin2 (pfpm2) and pfmdr1 copy numbers. We found multiple copies of pfpm2 in 1.1% of isolates. All isolates carried K13 wild-type alleles (3D7-like), except 4 novel polymorphisms (Leu619Leu, Phe656Ile, Val666Val, Gly690Gly). Prevalence of isolates with pfcrt mutant (K76T) allele was low (2.3%). Prevalence of isolates with pfdhps mutant alleles (A437G and K540E) was >80%, indicating persistence of sulfadoxine/pyrimethamine resistance; however, markers of artemisinin were absent, and markers of piperaquine resistance were low. Piperaquine resistance isolates may spread in Mozambique as dihydroartemisinin/piperaquine drug pressure increases. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Centers for Disease Control and Prevention | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3201/eid2401.170864 | - |
dc.relation.ispartof | Emerging Infectious Diseases, 2018, vol. 24, num. 1, p. 40-48 | - |
dc.relation.uri | http://dx.doi.org/10.3201/eid2401.170864 | - |
dc.rights | Domini públic / Public domain | - |
dc.rights.uri | http://creativecommons.org/publicdomain/mark/1.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Plasmodium falciparum | - |
dc.subject.classification | Moçambic | - |
dc.subject.other | Plasmodium falciparum | - |
dc.subject.other | Mozambique | - |
dc.title | Drug-Resistant Polymorphisms and Copy Numbers in Plasmodium falciparum, Mozambique, 2015 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-12-27T18:59:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29260689 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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gupta2018_2846.pdf | 833.22 kB | Adobe PDF | View/Open |
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