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http://hdl.handle.net/2445/119667
Title: | New GABA amides activating GABAa-receptors |
Author: | Raster, Peter Späth, Andreas Bultakova, Svetlana Gorostiza Langa, Pablo Ignacio König, Burkhard Bregestovski, Piotr |
Keywords: | Receptors de neurotransmissors Neuroquímica Neurotransmitter receptors Neurochemistry |
Issue Date: | 2013 |
Publisher: | Beilstein Institute |
Abstract: | We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABA A -receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were previously reported to be partial, full or superagonists. In our hands these compounds were not able to activate GABA A -receptor channels in whole-cell patch-clamp recordings. New GABA-amides, however, gave moderate activation responses with a clear structure-activity relation- ship suggesting some of these compounds as promising molecular tools for the functional analysis of GABA A -receptors |
Note: | Reproducció del document publicat a: https://doi.org/10.3762/bjoc.9.42 |
It is part of: | Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 406-410 |
URI: | http://hdl.handle.net/2445/119667 |
Related resource: | https://doi.org/10.3762/bjoc.9.42 |
ISSN: | 1860-5397 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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