Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/119822
Title: | EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation |
Author: | Silva, Joana Aivio, Suvi Knobel, Philip A. Bailey, Laura J. Casali, Andreu Vinaixa, Maria Garcia Cao, Isabel Coyaud, Étienne Jourdain, Alexis A. Pérez Ferreros, Pablo Rojas, Ana M. Antolin Fontes, Albert Samino Gené, Sara Raught, Brian González Reyes, Acaimo Ribas de Pouplana, Lluís Doherty, Aidan J. Yanes, Oscar Stracker, Travis H. |
Keywords: | Mitocondris Drosòfila melanogaster Homeòstasi Mitochondria Drosophila melanogaster Homeostasis |
Issue Date: | 15-Jan-2018 |
Publisher: | Macmillan |
Abstract: | Mitochondria are subcellular organelles that are critical for meeting the bioenergetic and biosynthetic needs of the cell. Mitochondrial function relies on genes and RNA species encoded both in the nucleus and mitochondria, and on their coordinated translation, import and respiratory complex assembly. Here, we characterize EXD2 (exonuclease 3′–5′ domain-containing 2), a nuclear-encoded gene, and show that it is targeted to the mitochondria and prevents the aberrant association of messenger RNAs with the mitochondrial ribosome. Loss of EXD2 results in defective mitochondrial translation, impaired respiration, reduced ATP production, increased reactive oxygen species and widespread metabolic abnormalities. Depletion of the Drosophila melanogaster EXD2 orthologue (CG6744) causes developmental delays and premature female germline stem cell attrition, reduced fecundity and a dramatic extension of lifespan that is reversed with an antioxidant diet. Our results define a conserved role for EXD2 in mitochondrial translation that influences development and ageing. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1038/s41556-017-0016-9 |
It is part of: | Nature Cell Biology, 2018, vol. 20, num. 2, p. 162-174 |
URI: | http://hdl.handle.net/2445/119822 |
Related resource: | http://dx.doi.org/10.1038/s41556-017-0016-9 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s41556-017-0016-9.pdf | 4.37 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.