Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/119908
Title: | Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study |
Author: | Montes, Ariana Perez-Pampin, Eva Navarro Sarabia, Federico Moreira, Virginia Rodríguez de la Serna, Arturo Magallares, Berta Vasilopoulos, Yiannis Sarafidou, Theologia Fernández-Nebro, Antonio Ordóñez, María del Carmen Narváez García, Francisco Javier Cañete Crespillo, Juan D. Márquez, Ana Pascual-Salcedo, Dora Joven, Beatriz Carreira, Patricia Moreno-Ramos, Manuel J. Caliz, Rafael Ferrer, Miguel Angel García-Portales, Rosa Blanco, Francisco J. Magro Checa, Cesar Raya, Enrique Valor, Lara Alegre-Sancho, Juan José Balsa, Alejandro Martín, Javier Plant, Darren Isaacs, John Morgan, Ann W. Barton, Anne Wilso, Anthony G. Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) Gomez Reino, Juan J. Gonzalez, Antonio |
Keywords: | Artritis reumatoide Estudi de casos Medicaments Teràpia genètica Rheumatoid arthritis Case studies Drugs Gene therapy |
Issue Date: | 18-Mar-2015 |
Publisher: | BioMed Central |
Abstract: | Introduction: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA). Methods: The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria. Results: An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication. Conclusions: Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13075-015-0571-z |
It is part of: | Arthritis Research & Therapy, 2015, vol. 17, p. 63 |
URI: | http://hdl.handle.net/2445/119908 |
Related resource: | https://doi.org/10.1186/s13075-015-0571-z |
ISSN: | 1478-6362 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
669946.pdf | 1.68 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License