Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/119967
Title: | Solvent-controlled diastereoselectivity in tryptophan-catalyzed Mannich reactions |
Author: | Valero González, Guillem León, Carlos M. Moyano i Baldoire, Albert |
Keywords: | Aminoàcids Catàlisi asimètrica Amino acids Enantioselective catalysis |
Issue Date: | 12-Jun-2015 |
Publisher: | De Gruyter Open |
Abstract: | Solvent effects in the L-tryptophan-catalyzed Mannich reaction between hydroxyacetone and glyoxylate imines have been examined. The use of a DMSO/1-butanol (4:1 v/v) mixture as solvent at rt provided the expected Mannich adducts in good yields, high anti-diastereoselectivity (up to 10.3:1 anti/syn ratio) and excellent enantioselectivities (up to >99.9% ee for the anti isomer) |
Note: | https://doi.org/10.1515/asorg-2015-0001 |
It is part of: | Asymmetric Catalysis, 2015, vol. 2, num. 1, p. 7-16 |
URI: | http://hdl.handle.net/2445/119967 |
Related resource: | https://doi.org/10.1515/asorg-2015-0001 |
ISSN: | 2300-4630 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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