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Title: TGFβ controls ovarian cancer cell proliferation
Author: Alsina Sanchís, Elisenda
Figueras i Amat, Agnès
Lahiguera, Álvaro
Gil-Martín, Marta
Pardo, Beatriz
Piulats, Josep M.
Martí, Lola
Ponce i Sebastià, Jordi
Matias-Guiu, Xavier
Vidal-Bel, August
Villanueva Garatachea, Alberto
Viñals Canals, Francesc
Keywords: Factors de creixement
Càncer d'ovari
Proliferació cel·lular
Growth factors
Ovarian cancer
Cell proliferation
Issue Date: 30-Jul-2017
Publisher: MDPI
Abstract: There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the signaling pathways involved is required. The Transforming Growth Factor (TGFβ) family controls different cellular responses in development and cell homeostasis. Disruption of TGFβ signaling has been implicated in many cancers, including ovarian cancer. This article considers the involvement of TGFβ in ovarian cancer progression, and reviews the various mechanisms that enable the TGFβ signaling pathway to control ovarian cancer cell proliferation. These mechanistic explanations support the therapeutic use of TGFβ inhibitors in ovarian cancer, which are currently in the early phases of development.
Note: Reproducció del document publicat a:
It is part of: International Journal of Molecular Sciences, 2017, vol. 18, num. 8, p. 1658
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Fisiològiques)

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