Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/120445
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Navarro Brugal, Gemma | - |
dc.contributor.author | Martínez-Pinilla, Eva | - |
dc.contributor.author | Sánchez Melgar, Alejandro | - |
dc.contributor.author | Ortiz, Raquel | - |
dc.contributor.author | Noé Mata, Verónica | - |
dc.contributor.author | Martín, Mairena | - |
dc.contributor.author | Ciudad i Gómez, Carlos Julián | - |
dc.contributor.author | Franco Fernández, Rafael | - |
dc.date.accessioned | 2018-03-05T12:54:05Z | - |
dc.date.available | 2018-03-05T12:54:05Z | - |
dc.date.issued | 2017-04-25 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/120445 | - |
dc.description.abstract | The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Genes that showed a significantly different expression (p<0.05, cut-off of a two-fold change) in mice fed with a control diet or a control diet containing trans-resveratrol were different in cortex, heart and skeletal muscle. In neocortex, we identified 4 up-regulated (Strap, Pkp4, Rab2a, Cpne3) and 22 down-regulated (Actn1, Arf3, Atp6v01, Atp1a3, Atp1b2, Cacng7, Crtc1, Dbn1, Dnm1, Epn1, Gfap, Hap, Mark41, Rab5b, Nrxn2, Ogt, Palm, Ptprn2, Ptprs, Syn2, Timp2, Vamp2) genes upon trans-resveratrol consumption. Network analysis of gene products provided evidence of plakophilin 4 up-regulation as a triggering factor for down-regulation of events related to synaptic vesicle transport and neurotransmitter release via underexpression of dynamin1 and Vamp2 (synaptobrevin 2) as node-gene drivers. Analysis by RT-qPCR of some of the selected genes in a glioma cell line showed that dynamin 1 mRNA was down-regulated even in acute trans-resveratrol treatments. Taken all together, these results give insight on the glial-neuronal networks involved in the neuroprotective role of trans-resveratrol. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0176067 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 4, p. e0176067 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0176067 | - |
dc.rights | cc-by (c) Navarro Brugal, Gemma et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Sistema nerviós central | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Central nervous system | - |
dc.title | A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 670388 | - |
dc.date.updated | 2018-03-05T12:54:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28441400 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
670388.pdf | 3.31 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License