Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/120809
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Massanella, Marta | - |
dc.contributor.author | Ouchi, Dan | - |
dc.contributor.author | Marfil, Silvia | - |
dc.contributor.author | Llibre, Josep María | - |
dc.contributor.author | Puertas Castro, Ma. Carmen | - |
dc.contributor.author | Buzón, María J. | - |
dc.contributor.author | Richman, Douglas D. | - |
dc.contributor.author | Orna, Elisa | - |
dc.contributor.author | Stevenson, Mario | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) | - |
dc.contributor.author | Negredo, Eugènia | - |
dc.contributor.author | Martínez Picado, Francisco Javier | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Blanco, Julià | - |
dc.date.accessioned | 2018-03-15T18:35:59Z | - |
dc.date.available | 2018-03-15T18:35:59Z | - |
dc.date.issued | 2014-12-02 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/120809 | - |
dc.description.abstract | BACKGROUND: HIV-1 infection increases plasma levels of inflammatory markers. Combination antiretroviral therapy (cART) does not restore inflammatory markers to normal levels. Since intensification of cART with raltegravir reduced CD8 T-cell activation in the Discor-Ral and IntegRal studies, we have evaluated the effect of raltegravir intensification on several soluble inflammation markers in these studies. METHODS: Longitudinal plasma samples (0-48 weeks) from the IntegRal (n = 67, 22 control and 45 intensified individuals) and the Discor-Ral studies (44 individuals with CD4 T-cell counts<350 cells/µl, 14 control and 30 intensified) were assayed for 25 markers. Mann-Whitney, Wilcoxon, Spearman test and linear mixed models were used for analysis. RESULTS: At baseline, different inflammatory markers were strongly associated with HCV co-infection, lower CD4 counts and with cART regimens (being higher in PI-treated individuals), but poorly correlated with detection of markers of residual viral replication. Although raltegravir intensification reduced inflammation in individuals with lower CD4 T-cell counts, no effect of intensification was observed on plasma markers of inflammation in a global analysis. An association was found, however, between reductions in immune activation and plasma levels of the coagulation marker D-dimer, which exclusively decreased in intensified patients on protease inhibitor (PI)-based cART regimens (P = 0.040). CONCLUSIONS: The inflammatory profile in treated HIV-infected individuals showed a complex association with HCV co-infection, the levels of CD4 T cells and the cART regimen. Raltegravir intensification specifically reduced D-dimer levels in PI-treated patients, highlighting the link between cART composition and residual viral replication; however, raltegravir had little effect on other inflammatory markers. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0114142 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 12, p. e114142 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0114142 | - |
dc.rights | cc-by (c) Massanella, Marta et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Antiretroviral agents | - |
dc.title | Different Plasma Markers of Inflammation Are Influenced by Immune Recovery and cART Composition or Intensification in Treated HIV Infected Individuals | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 649155 | - |
dc.date.updated | 2018-03-15T18:35:59Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/223131/EU//CHAIN | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25462535 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
649155.pdf | 838.79 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License