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http://hdl.handle.net/2445/120822
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DC Field | Value | Language |
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dc.contributor.author | Elks, Cathy E. | - |
dc.contributor.author | Heude, Barbara | - |
dc.contributor.author | De Zegher, Franscis | - |
dc.contributor.author | Barton, Sheila J. | - |
dc.contributor.author | Clément, Karine | - |
dc.contributor.author | Inskip, Hazel M. | - |
dc.contributor.author | Koudou, Yves | - |
dc.contributor.author | Cooper, Cyrus | - |
dc.contributor.author | Dunger, David B. | - |
dc.contributor.author | Ibáñez Toda, Lourdes | - |
dc.contributor.author | Charles, Marie-Aline | - |
dc.contributor.author | Ong, Ken K. | - |
dc.date.accessioned | 2018-03-16T10:56:22Z | - |
dc.date.available | 2018-03-16T10:56:22Z | - |
dc.date.issued | 2014-12-01 | - |
dc.identifier.issn | 2168-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/120822 | - |
dc.description.abstract | IMPORTANCE: Patterns of body size and body composition associated with genetic obesity susceptibility inform the mechanisms that increase obesity risk. OBJECTIVE: To test associations between genetic obesity susceptibility, represented by a combined obesity risk-allele score, and body size or body composition at birth to age 5 years. DESIGN, SETTING, AND PARTICIPANTS: A total of 3031 children from 4 birth cohort studies in England, France, and Spain were included in a meta-analysis. EXPOSURES: A combined obesity risk-allele score was calculated from genotypes at 16 variants identified by genome-wide association studies of adult body mass index (BMI). MAIN OUTCOMES AND MEASURES: Outcomes were age- and sex-adjusted SD scores (SDS) for weight, length/height, BMI, fat mass, lean mass, and percentage of body fat at birth as well as at ages 1, 2 to 3, and 4 to 5 years. RESULTS: The obesity risk-allele score was not associated with infant size at birth; at age 1 year it was positively associated with weight (β [SE], 0.020 [0.008] SDS per allele; P = .009) and length (β [SE], 0.020 [0.008] SDS per allele; P = .01), but not with BMI (β [SE], 0.013 [0.008] SDS per allele; P = .11). At age 2 to 3 years these associations were stronger (weight: β [SE], 0.033 [0.008] SDS per allele; P < .001; height: β [SE], 0.025 [0.008] SDS per allele; P < .001) and were also seen for BMI (β [SE], 0.024 [0.008] SDS per allele; P = .003). The obesity risk-allele score was positively associated with both postnatal fat mass (1 year: β [SE], 0.032 [0.017] SDS per allele; P = .05; 2-3 years: β [SE], 0.049 [0.018] SDS per allele; P = .006; and 4-5 years: β [SE], 0.028 [0.011] SDS per allele; P = .009) and postnatal lean mass (1 year: β [SE], 0.038 [0.014] SDS per allele; P = .008; 2-3 years: β [SE], 0.064 [0.017] SDS per allele; P < .001; and 4-5 years: β [SE], 0.047 [0.011] SDS per allele; P < .001), but not with the percentage of body fat (P > .15 at all ages). CONCLUSIONS AND RELEVANCE: Genetic obesity susceptibility appears to promote a normally partitioned increase in early postnatal, but not prenatal, growth. These findings suggest that symmetrical rapid growth may identify infants with high life-long susceptibility for obesity. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Medical Association | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1001/jamapediatrics.2014.1619 | - |
dc.relation.ispartof | JAMA Pediatrics, 2014, vol. 168, num. 12, p. 1122-1130 | - |
dc.relation.uri | https://doi.org/10.1001/jamapediatrics.2014.1619 | - |
dc.rights | (c) American Medical Association, 2014 | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Teixit adipós | - |
dc.subject.classification | Pes corporal | - |
dc.subject.classification | Obesitat | - |
dc.subject.classification | Anglaterra | - |
dc.subject.classification | França | - |
dc.subject.classification | Espanya | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.other | Adipose tissues | - |
dc.subject.other | Body weight | - |
dc.subject.other | Obesity | - |
dc.subject.other | England | - |
dc.subject.other | France | - |
dc.subject.other | Spain | - |
dc.subject.other | Genetics | - |
dc.subject.other | Risk factors in diseases | - |
dc.title | Associations between genetic obesity susceptibility and early postnatal fat and lean mass: an individual participant meta-analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 642405 | - |
dc.date.updated | 2018-03-16T10:56:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25329327 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
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642405.pdf | 298.63 kB | Adobe PDF | View/Open |
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