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DC Field | Value | Language |
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dc.contributor.author | Benavente, Yolanda | - |
dc.contributor.author | Campo Güerri, Elias | - |
dc.date.accessioned | 2018-03-19T10:55:36Z | - |
dc.date.available | 2018-03-19T10:55:36Z | - |
dc.date.issued | 2017-02-06 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/120862 | - |
dc.description.abstract | Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/ncomms14175 | - |
dc.relation.ispartof | Nature Communications, 2017, vol. 8, num. 14175 | - |
dc.relation.uri | https://doi.org/10.1038/ncomms14175 | - |
dc.rights | cc-by (c) Benavente, Yolanda et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Cancer | - |
dc.title | Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 671353 | - |
dc.date.updated | 2018-03-19T10:55:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28165464 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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