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http://hdl.handle.net/2445/120949
Title: | SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway |
Author: | Santos Barriopedro, Irene Bosch Presegué, Laia Marazuela Duque, Anna Torre Gómez, Carolina de la Colomer, Carlota Vàzquez Prat, Berta N. Fuhrmann, Thomas Martínez-Pastor, Bárbara Lu, Wenfu Braun, Thomas Bober, Eva Jenuwein, Thomas Serrano, Lourdes Esteller, Manel Cheng, Zhenbang Barceló-Batllori, Sílvia Mostoslavsky, Raúl Espinosa, Lluís Vaquero García, Alejandro |
Keywords: | Cromatina Epigenètica Histones Chromatin Epigenetics Histones |
Issue Date: | 9-Jan-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Sirtuins are NAD+-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an accelerated aging phenotype directly linked to hyperactivation of the NF-κB pathway. Here we show that SirT6 binds to the H3K9me3-specific histone methyltransferase Suv39h1 and induces monoubiquitination of conserved cysteines in the PRE-SET domain of Suv39h1. Following activation of NF-κB signaling Suv39h1 is released from the IκBα locus, subsequently repressing the NF-κB pathway. We propose that SirT6 attenuates the NF-κB pathway through IκBα upregulation via cysteine monoubiquitination and chromatin eviction of Suv39h1. We suggest a mechanism based on SirT6-mediated enhancement of a negative feedback loop that restricts the NF-κB pathway. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-017-02586-x |
It is part of: | Nature Communications, 2018, vol. 9, num. 1, p. 101 |
URI: | http://hdl.handle.net/2445/120949 |
Related resource: | https://doi.org/10.1038/s41467-017-02586-x |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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