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DC Field | Value | Language |
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dc.contributor.author | Barceló, Antonia | - |
dc.contributor.author | Esquinas López, Cristina | - |
dc.contributor.author | Robles, Juan | - |
dc.contributor.author | Piérola, Javier | - |
dc.contributor.author | Peña, Mónica de la | - |
dc.contributor.author | Aguilar, Irene | - |
dc.contributor.author | Morell-Garcia, Daniel | - |
dc.contributor.author | Alonso, Alberto | - |
dc.contributor.author | Toledo Pons, Nuria | - |
dc.contributor.author | Sánchez de la Torre, Manuel | - |
dc.contributor.author | Barbé, Ferran | - |
dc.date.accessioned | 2018-03-26T12:10:14Z | - |
dc.date.available | 2018-03-26T12:10:14Z | - |
dc.date.issued | 2016-10-01 | - |
dc.identifier.issn | 1389-9457 | - |
dc.identifier.uri | http://hdl.handle.net/2445/121109 | - |
dc.description.abstract | Background: obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: the results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.sleep.2016.01.019 | - |
dc.relation.ispartof | Sleep Medicine, 2016, vol. 26, p. 12-15 | - |
dc.relation.uri | https://doi.org/10.1016/j.sleep.2016.01.019 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) | - |
dc.subject.classification | Proteïnes portadores | - |
dc.subject.classification | Fixació de proteïnes | - |
dc.subject.classification | Síndrome metabòlica | - |
dc.subject.classification | Absorció intestinal | - |
dc.subject.classification | Síndromes d'apnea del son | - |
dc.subject.classification | Obesitat | - |
dc.subject.other | Carrier proteins | - |
dc.subject.other | Protein binding | - |
dc.subject.other | Metabolic syndrome | - |
dc.subject.other | Intestinal absorption | - |
dc.subject.other | Sleep apnea syndromes | - |
dc.subject.other | Obesity | - |
dc.title | Gut epithelial barrier markers in patients with obstructive sleep apnea | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 678838 | - |
dc.date.updated | 2018-03-26T12:10:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28007354 | - |
Appears in Collections: | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) |
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678838.pdf | 684.91 kB | Adobe PDF | View/Open |
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