Please use this identifier to cite or link to this item:
Title: A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk
Author: Castro-Quezada, Itandehui
Sánchez-Villegas, Almudena
Estruch Riba, Ramon
Salas Salvadó, Jordi
Corella Piquer, Dolores
Schröder, Helmut, 1958-
Alvarez Pérez, Jacqueline
Ruiz López, María Dolores
Artacho, Reyes
Ros Rahola, Emilio
Bulló, Mònica
Covas Planells, María Isabel
Ruiz-Gutiérrez, Valentina
Ruiz Canela, Miguel
Buil Cosiales, Pilar
Gómez Gracia, Enrique
Lapetra, José
Pintó Sala, Xavier
Arós, Fernando
Fiol Sala, Miguel
Lamuela Raventós, Rosa Ma.
Martínez-González, Miguel Ángel, 1957-
Serra Majem, Lluís
Keywords: Glucèmia
Malalties cardiovasculars
Blood sugar
Cardiovascular diseases
Issue Date: 24-Sep-2014
Publisher: Public Library of Science (PLoS)
Abstract: OBJECTIVE: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. MATERIAL AND METHODS: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food frequency questionnaire (FFQ). We assigned GI values of each item by a 5-step methodology, using the International Tables of GI and GL Values. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) and their 95% CI for mortality, according to quartiles of energy-adjusted dietary GI/GL. To assess repeated measures of exposure, we updated GI and GL intakes from the yearly FFQs and used Cox models with time-dependent exposures. RESULTS: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). As compared to participants in the lowest quartile of baseline dietary GI, those in the highest quartile showed an increased risk of all-cause mortality [HR = 2.15 (95% CI: 1.15-4.04); P for trend  = 0.012]. In the repeated-measures analyses using as exposure the yearly updated information on GI, we observed a similar association. Dietary GL was associated with all-cause mortality only when subjects were younger than 75 years. CONCLUSIONS: High dietary GI was positively associated with all-cause mortality in elderly population at high cardiovascular risk.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2014, vol. 9, num. 9, p. e107968
Related resource:
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
647281.pdf215.08 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons