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Title: Cationic supramolecular hydrogels for overcoming the skin barrier in drug delivery
Author: Limón Magaña, David
Jiménez Newman, Claire
Rodrigues, Ana Mafalda Nunes
González Campo, Arántzazu
Amabilino, David B.
Calpena Campmany, Ana Cristina
Pérez García, M. Lluïsa (Maria Lluïsa)
Keywords: Química supramolecular
Malalties de la pell
Supramolecular chemistry
Skin diseases
Issue Date: 1-May-2017
Publisher: Wiley-VCH Verlag
Abstract: A cationic bis‐imidazolium‐based amphiphile was used to form thermoreversible nanostructured supramolecular hydrogels incorporating neutral and cationic drugs for the topical treatment of rosacea. The concentration of the gelator and the type and concentration of the drug incorporated were found to be factors that strongly influenced the gelling temperature, gel‐formation period, and overall stability and morphology. The incorporation of brimonidine tartrate resulted in the formation of the most homogeneous material of the three drugs explored, whereas the incorporation of betamethasone resulted in a gel with a completely different morphology comprising linked particles. NMR spectroscopy studies proved that these gels kept the drug not only at the interstitial space but also within the fibers. Due to the design of the gelator, drug release was up to 10 times faster and retention of the drug within the skin was up to 20 times more effective than that observed for commercial products. Experiments in vivo demonstrated the rapid efficacy of these gels in reducing erythema, especially in the case of the gel with brimonidine. The lack of coulombic attraction between the gelator-host and the guest-drug seemed particularly important in highly effective release, and the intermolecular interactions operating between them were found to lie at the root of the excellent properties of the materials for topical delivery and treatment of rosacea.
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It is part of: ChemistryOpen, 2017, num. 6, p. 585-598
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ISSN: 2191-1363
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))

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