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DC Field | Value | Language |
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dc.contributor.author | Martín Loeches, Ignacio | - |
dc.contributor.author | Valles, Xavier | - |
dc.contributor.author | Menéndez, Rosario | - |
dc.contributor.author | Sibila Vidal, Oriol | - |
dc.contributor.author | Montull, Beatriz | - |
dc.contributor.author | Cillóniz, Catia | - |
dc.contributor.author | Artigas, Antonio | - |
dc.contributor.author | Torres Martí, Antoni | - |
dc.date.accessioned | 2018-04-18T17:12:55Z | - |
dc.date.available | 2018-04-18T17:12:55Z | - |
dc.date.issued | 2014-07-05 | - |
dc.identifier.issn | 1465-993X | - |
dc.identifier.uri | http://hdl.handle.net/2445/121710 | - |
dc.description.abstract | INTRODUCTION: Treatment failure in community-acquired-pneumonia (CAP) patients is associated with a high mortality rate, and therefore are a matter of great concern in clinical management. Those patients have increased mortality and are a target population for randomized clinical trials. METHODS: A case-control study was performed in patients with CAP (non-failure cases vs. failure cases, discriminating by late and early failure). CRP, PCT, interleukin 1, 6, 8 and 10 and TNF were determined at days 1 and 3 of hospitalization. RESULTS: A total of 253 patients were included in this study where 83 patients presented treatment failure. Of these, 40 (48.2%) had early failure. A discriminative effect was found for a higher CURB-65 score among late failure patients (p = 0.004). A significant increase on day 1 of hospitalization in CRP (p < 0.001), PCT (p = 0.004), IL-6 (p < 0.001) and IL-8 (p = 0.02), and a decrease in IL-1 (p = 0.06) in patients with failure was observed compared with patients without failure. On day 3, only the increase in CRP (p < 0.001), PCT (p = 0.007) and IL-6 (p < 0.001) remained significant. Independent predictors for early failure were higher IL-6 levels on day 1 (OR = 1.78, IC = 1.2-2.6) and pleural effusion (OR = 2.25, IC = 1.0-5.3), and for late failure, higher PCT levels on day 3 (OR = 1.60, IC = 1.0-2.5), CURB-65 score ≥ 3 (OR = 1.43, IC = 1.0-2.0), and multilobar involvement (OR = 4.50, IC = 2.1-9.9). CONCLUSIONS: There was a good correlation of IL-6 levels and CAP failure and IL-6 & PCT with late CAP failure. Pleural effusion and multilobar involvement were simple clinical predictors of early and late failure, respectively. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/1465-9921-15-75 | - |
dc.relation.ispartof | Respiratory Research, 2014, vol. 15, p. 75 | - |
dc.relation.uri | https://doi.org/10.1186/1465-9921-15-75 | - |
dc.rights | cc-by (c) Martin Loeches, Ignacio et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Pneumònia adquirida a la comunitat | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Pneumònia | - |
dc.subject.other | Community-acquired pneumonia | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Pneumonia | - |
dc.title | Predicting treatment failure in patients with community acquired pneumonia: a case-control study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 645181 | - |
dc.date.updated | 2018-04-18T17:12:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 830706 | - |
dc.identifier.pmid | 24996572 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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