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http://hdl.handle.net/2445/121735
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DC Field | Value | Language |
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dc.contributor.author | Srand, Vibeke | - |
dc.contributor.author | Levy, Roger A. | - |
dc.contributor.author | Cervera i Segura, Ricard, 1960- | - |
dc.contributor.author | Petri, Michelle A. | - |
dc.contributor.author | Birch, Helen | - |
dc.contributor.author | Freimuth, William W. | - |
dc.contributor.author | Zhong, Z.John | - |
dc.contributor.author | Clarke, Ann E. | - |
dc.contributor.author | BLISS-52 and -76 Study Groups | - |
dc.date.accessioned | 2018-04-20T09:52:02Z | - |
dc.date.available | 2018-04-20T09:52:02Z | - |
dc.date.issued | 2014-03-22 | - |
dc.identifier.issn | 0003-4967 | - |
dc.identifier.uri | http://hdl.handle.net/2445/121735 | - |
dc.description.abstract | OBJECTIVE: Assess the effects of belimumab treatment plus standard systemic lupus erythematosus (SLE) therapy on health-related quality of life (HRQOL) in patients with active, autoantibody-positive SLE. METHODS: Patients received standard therapy plus placebo or belimumab 1 or 10 mg/kg in two multicentre, randomised controlled trials of 52 (BLISS-52; N=865) and 76 (BLISS-76; N=819) weeks' duration. Responders were evaluated by SLE Responder Index at week 52. Patient-reported outcome assessments included SF-36, Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue, and EQ-5D. RESULTS: Mean SF-36 Physical Component Summary (PCS) scores at week 24 was a major secondary endpoint. Baseline SF-36 scores were 1.5 SDs below age-/sex-matched US norms with similar improvement at week 24 across treatment groups. Mean changes from baseline in PCS scores were significantly (p<0.05) greater with belimumab 1 mg/kg (4.20) and 10 mg/kg (4.18) versus placebo (2.96) in BLISS-52, week 52. In BLISS-76, significantly (p<0.05) greater improvements were seen with belimumab 1 mg/kg in PCS (belimumab 1 mg/kg=4.37, 10 mg/kg=3.41 vs placebo=2.85) and Mental Component Summary (MCS) scores (belimumab 1 mg/kg=3.14, 10 mg/kg=2.70 vs placebo=1.40) at week 52, and in MCS score at week 76 (belimumab 1 mg/kg=3.05, 10 mg/kg=2.28 vs placebo=1.36). In pooled analysis, significantly greater improvements in PCS, SF-36 vitality domain, and FACIT-Fatigue scores at week 52 were evident with both belimumab doses. CONCLUSIONS: The clinically meaningful improvements in HRQOL in autoantibody-positive patients with active SLE treated with belimumab and standard therapy are consistent with the reductions in disease activity observed in these trials. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/annrheumdis-2012-202865 | - |
dc.relation.ispartof | Annals of the Rheumatic Diseases, 2014, vol. 73, num. 5, p. 838-844 | - |
dc.relation.uri | https://doi.org/10.1136/annrheumdis-2012-202865 | - |
dc.rights | (c) BMJ Publishing Group, 2014 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Lupus eritematós | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Tractament del dolor | - |
dc.subject.classification | Qualitat de vida | - |
dc.subject.other | Lupus erythematosus | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Pain treatment | - |
dc.subject.other | Quality of life | - |
dc.title | Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 643131 | - |
dc.date.updated | 2018-04-20T09:52:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23524886 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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643131.pdf | 1.06 MB | Adobe PDF | View/Open |
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