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http://hdl.handle.net/2445/121775
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DC Field | Value | Language |
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dc.contributor.author | Moncunill, Gemma | - |
dc.contributor.author | Mayor Aparicio, Alfredo Gabriel | - |
dc.contributor.author | Jiménez, Alfons | - |
dc.contributor.author | Nhabomba, Augusto J. | - |
dc.contributor.author | Puyol, Laura | - |
dc.contributor.author | Manaca, Maria Nélia | - |
dc.contributor.author | Barrios, Diana | - |
dc.contributor.author | Cisteró, Pau | - |
dc.contributor.author | Guinovart, Caterina | - |
dc.contributor.author | Aguilar, Ruth | - |
dc.contributor.author | Bardají, Azucena | - |
dc.contributor.author | Pinazo, Maria-Jesus | - |
dc.contributor.author | Angov, Evelina | - |
dc.contributor.author | Dutta, Sheetij | - |
dc.contributor.author | Chitnis, Chetan E. | - |
dc.contributor.author | Muñoz, José | - |
dc.contributor.author | Gascón i Brustenga, Joaquim | - |
dc.contributor.author | Dobaño, Carlota, 1969- | - |
dc.date.accessioned | 2018-04-23T11:20:09Z | - |
dc.date.available | 2018-04-23T11:20:09Z | - |
dc.date.issued | 2013-02-21 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/121775 | - |
dc.description.abstract | Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected from naïve Mozambican children (n = 48), European adults (naïve travelers, n = 22; expatriates with few prior malaria exposures, n = 15) and Mozambican adults with long-life malaria exposure (n = 99) during and after a malaria episode were analyzed for IgG against merozoite proteins by Luminex and against infected erythrocytes by flow cytometry. Cytokines and chemokines were analyzed in plasmas/sera by suspension array technology. No differences were detected between children and adults with a primary infection, with the exception of higher IgG levels against 3D7 MSP-142 (P = 0.030) and a P. falciparum isolate (P = 0.002), as well as higher IL-12 (P = 0.020) in children compared to other groups. Compared to malaria-exposed adults, children, travelers and expatriates had higher concentrations of IFN-γ (P≤0.0090), IL-2 (P≤0.0379) and IL-8 (P≤0.0233). Children also had higher IL-12 (P = 0.0001), IL-4 (P = 0.003), IL-1β (P = 0.024) and TNF (P = 0.006) levels compared to malaria-exposed adults. Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A TH1/pro-inflammatory response was the hallmark of non-immune subjects. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0055756 | - |
dc.relation.ispartof | PLoS One, 2013 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0055756 | - |
dc.rights | cc-by (c) Moncunill, Gemma et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Plasmodium falciparum | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Malaria | - |
dc.subject.other | Plasmodium falciparum | - |
dc.title | Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 679595 | - |
dc.date.updated | 2018-04-23T11:20:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23437061 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (ISGlobal) |
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679595.pdf | 378.12 kB | Adobe PDF | View/Open |
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