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Title: Omalizumab efficacy in cases of chronic spontaneous urticaria is not explained by the inhibition of sera activity in effector cells
Author: Serrano Candelas, Eva
Martínez Aranguren, Rubén
Vega, Olga
Gastaminza, Gabriel
Bartra Tomàs, Joan
Audicana, Maria Teresa
Núñez Córdoba, Jorge M.
Algorta, Jaime
Valero, Antonio
Martín Andorrà, Margarita
Ferrer, Marta
Keywords: Inflamació
Teràpia genètica
Gene therapy
Issue Date: 21-Aug-2017
Publisher: Nature Publishing Group
Abstract: Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involvement is not clear, suggesting the involvement of additional mechanisms of action. In this study, we sought to investigate the ability of OmAb to inhibit mast cell and basophil degranulation induced by sera from CSU patients. For this purpose, we performed a comparison between the in vitro incubation of sera from CSU patients treated with OmAb and the in vivo administration of OmAb in a clinical trial. We found that OmAb added in vitro to sera from CSU patients did not modify the ability of the sera to induce cell degranulation. Similarly, the sera from patients treated with OmAb in the context of the clinical trial who had a good clinical outcome maintained the capacity to activate mast cells and basophils. Thus, we conclude that the beneficial activity of OmAb does not correlate with the ability of patient sera to induce cell degranulation.
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It is part of: Scientific Reports, 2017, vol. 7, num. 8985
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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