Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/122235
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DC Field | Value | Language |
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dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.contributor.author | Escriche, Marisol | - |
dc.contributor.author | Burgueño, Javier | - |
dc.contributor.author | Angulo, Ester | - |
dc.contributor.author | Casadó, Vicent | - |
dc.contributor.author | Soloviev, Mikhail M. | - |
dc.contributor.author | Canela Campos, Enric I. | - |
dc.contributor.author | Mallol Montero, Josefa | - |
dc.contributor.author | Chan, Wai-Yee | - |
dc.contributor.author | Lluís i Biset, Carme | - |
dc.contributor.author | McIlhinney, R. A. Jeffrey | - |
dc.contributor.author | Franco Fernández, Rafael | - |
dc.date.accessioned | 2018-05-09T12:04:07Z | - |
dc.date.available | 2018-05-09T12:04:07Z | - |
dc.date.issued | 2001-05 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122235 | - |
dc.description.abstract | Recently, evidence has emerged that seven transmembrane G protein-coupled receptors may be present as homo- and heteromers in the plasma membrane. Here we describe a new molecular and functional interaction between two functionally unrelated types of G protein-coupled receptors, namely the metabotropic glutamate type 1alpha (mGlu(1alpha) receptor) and the adenosine A1 receptors in cerebellum, primary cortical neurons, and heterologous transfected cells. Co-immunoprecipitation experiments showed a close and subtype-specific interaction between mGlu(1alpha) and A1 receptors in both rat cerebellar synaptosomes and co-transfected HEK-293 cells. By using transiently transfected HEK-293 cells a synergy between mGlu(1alpha) and A1 receptors in receptor-evoked [Ca(2+)](i) signaling has been shown. In primary cultures of cortical neurons we observed a high degree of co-localization of the two receptors, and excitotoxicity experiments in these cultures also indicate that mGlu(1alpha) and A1 receptors are functionally related. Our results provide a molecular basis for adenosine/glutamate receptors cross-talk and open new perspectives for the development of novel agents to treat neuropsychiatric disorders in which abnormal glutamatergic neurotransmission is involved. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Biochemistry and Molecular Biology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1074/jbc.M006960200 | - |
dc.relation.ispartof | Journal of Biological Chemistry, 2001, vol. 276, num. 21, p. 18345-18351 | - |
dc.relation.uri | https://doi.org/10.1074/jbc.M006960200 | - |
dc.rights | (c) American Society for Biochemistry and Molecular Biology, 2001 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Adenosina | - |
dc.subject.classification | Neurotransmissió | - |
dc.subject.classification | Àcid glutàmic | - |
dc.subject.other | Adenosine | - |
dc.subject.other | Neural transmission | - |
dc.subject.other | Glutamic acid | - |
dc.title | Metabotropic glutamate 1α and adenosine A1 receptors assemble into functionally interacting complexes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 180114 | - |
dc.date.updated | 2018-05-09T12:04:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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180114.pdf | 1.15 MB | Adobe PDF | View/Open |
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