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http://hdl.handle.net/2445/122383
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DC Field | Value | Language |
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dc.contributor.author | Cabello, Nuria | - |
dc.contributor.author | Remelli, Rosaria | - |
dc.contributor.author | Canela, Laia | - |
dc.contributor.author | Soriguera, Ana | - |
dc.contributor.author | Mallol Montero, Josefa | - |
dc.contributor.author | Canela Campos, Enric I. | - |
dc.contributor.author | Robbins, Melanie J. | - |
dc.contributor.author | Lluís i Biset, Carme | - |
dc.contributor.author | Franco Fernández, Rafael | - |
dc.contributor.author | McIlhinney, R. A. Jeffrey | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.date.accessioned | 2018-05-15T14:50:52Z | - |
dc.date.available | 2018-05-15T14:50:52Z | - |
dc.date.issued | 2007-04-20 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122383 | - |
dc.description.abstract | Receptors for neurotransmitters require scaffolding proteins for membrane microdomain targeting and for regulating receptor function. Using a yeast two-hybrid screen, α-actinin-1, a major F-actin cross-linking protein, was identified as a binding partner for the C-terminal domain of metabotropic glutamate receptor type 5b (mGlu5b receptor). Co-expression, co-immunoprecipitation, and pull-down experiments showed a close and specific interaction between mGlu5b receptor and α-actinin-1 in both transfected HEK-293 cells and rat striatum. The interaction of α-actinin-1 with mGlu5b receptor modulated the cell surface expression of the receptor. This was dependent on the binding of α-actinin-1 to the actin cytoskeleton. In addition, the α-actinin-1/mGlu5b receptor interaction regulated receptor-mediated activation of the mitogen-activated protein kinase pathway. Together, these findings indicate that there is an α-actinin-1-dependent mGlu5b receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Biochemistry and Molecular Biology | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1074/jbc.M608880200 | - |
dc.relation.ispartof | Journal of Biological Chemistry, 2007, vol. 282, num. 16, p. 12143-12153 | - |
dc.relation.uri | https://doi.org/10.1074/jbc.M608880200 | - |
dc.rights | (c) American Society for Biochemistry and Molecular Biology, 2007 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Àcid glutàmic | - |
dc.subject.classification | Neurotransmissió | - |
dc.subject.other | Glutamic acid | - |
dc.subject.other | Neural transmission | - |
dc.title | Actin-binding protein α-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 549463 | - |
dc.date.updated | 2018-05-15T14:50:52Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
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549463.pdf | 607.37 kB | Adobe PDF | View/Open |
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